ArticleBiomedical optics express2023
Liver injury monitoring using dynamic fluorescence molecular tomography based on a time-energy difference strategy.
Article in Biomedical optics express, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Dynamic fluorescence molecular tomography (DFMT) is a promising molecular imaging technique that offers the potential to monitor fast kinetic behaviors within small animals in three dimensions. Early monitoring of liver disease requires the ability to distinguish and analyze normal and injured liver tissues. However, the inherent ill-posed nature of the problem and energy signal interference between the normal and injured liver regions limit the practical application of liver injury monitoring. In this study, we propose a novel strategy based on time and energy, leveraging the temporal correlation in fluorescence molecular imaging (FMI) sequences and the metabolic differences between normal and injured liver tissue. Additionally, considering fluorescence signal distribution disparity between the injured and normal regions, we designed a universal Golden Ratio Primal-Dual Algorithm (GRPDA) to reconstruct both the normal and injured liver regions. Numerical simulation and
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