Evidence map›Paper›PMID 37854507›Full record

ArticleNeurophotonics2023

Functional near-infrared spectroscopy-based prefrontal cortex oxygenation during working memory tasks in sickle cell disease.

John Sunwoo, Payal Shah, Wanwara Thuptimdang, Maha Khaleel, Patjanaporn Chalacheva, Roberta M Kato, Thomas D Coates, Michael C K Khoo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurophotonics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

John SunwooUniversity of Southern California, Department of Biomedical Engineering, Los Angeles, California, United States.ORCID https://orcid.org/0000-0003-4314-7232
Payal ShahChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Hematology Section of Children's Center for Cancer, Blood Disease and Bone Marrow Transplantation, Los Angeles, California, United States.
Wanwara ThuptimdangUniversity of Southern California, Department of Biomedical Engineering, Los Angeles, California, United States.
Maha KhaleelChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Hematology Section of Children's Center for Cancer, Blood Disease and Bone Marrow Transplantation, Los Angeles, California, United States.
Patjanaporn ChalachevaUniversity of Southern California, Department of Biomedical Engineering, Los Angeles, California, United States.
Roberta M KatoChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Division of Pediatric Pulmonology, Los Angeles, California, United States.
Thomas D CoatesChildren's Hospital Los Angeles, Keck School of Medicine, University of Southern California, Hematology Section of Children's Center for Cancer, Blood Disease and Bone Marrow Transplantation, Los Angeles, California, United States.
Michael C K KhooUniversity of Southern California, Department of Biomedical Engineering, Los Angeles, California, United States.
University of Southern California · USCarnegie Mellon University · USChildren's Hospital of Los Angeles · USPrince of Songkla University · TH

Funding

TrainingP41EB001978 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KHOO, MICHAEL C K · 2003 to 2017
$18.1M
Neuromodulatory Mechanisms and Regional Autonomic Dysregulation in the Development of Pain in Sickle Cell Disease PatientsU01HL117718 · NHLBI · CHILDREN'S HOSPITAL OF LOS ANGELES · PI COATES, THOMAS DUANE, KHOO, MICHAEL C K · 2013 to 2017
$9.6M
NHLBI NIH HHS U01 HL117718NIBIB NIH HHS P41 EB001978
6 · The paper itself

Abstract

Significance: Sickle cell disease (SCD), characterized by painful vaso-occlusive crises, is associated with cognitive decline. However, objective quantification of cognitive decline in SCD remains a challenge, and the associated hemodynamics are unknown. Aim: To address this, we utilized functional near-infrared spectroscopy (fNIRS) to measure prefrontal cortex (PFC) oxygenation responses to Approach: We quantified the PFC oxygenation rate as an index of cognitive activity in each group and compared them. In half of the participants, a Stroop test was administered before they started Results: In SCD compared to healthy controls, we found that (1) under a high baseline stress level, there were significantly greater oxygenation responses during the 2-back task, further elevated with histories of stroke; (2) there was a marginally slower Conclusions: Additional requirements for processing time, PFC resources, and PFC oxygenation in SCD patients offer an important basis for understanding their cognitive decline and highlight the potential of fNIRS for evaluating cognitive functions.

Indexed as

cognitive declinefunctional near-infrared spectroscopyN-back working memory tasksprefrontal cortexsickle cell diseasestroke

Identifiers

PMID37854507
PMCPMC10581024
OpenAlexW4387701073

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.