Evidence map›Paper›PMID 37853514›Full record

ReviewThe Journal of infectious diseases2024

Chagas Disease Diagnostic Practices at Four Major Hospital Systems in California and Texas.

Emily A Kelly, Jose I Echeverri Alegre, Katherine Promer, Jesica Hayon, Roumen Iordanov, Khuzaima Rangwalla, Jerry J Zhang, Zian Fang, Cindy Huang, Cassiana E Bittencourt and 5 more

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Emily A KellyDepartment of Laboratory Medicine, University of California, SanFrancisco, San Francisco, California, USA.ORCID 0000-0003-2986-0285
Jose I Echeverri AlegreSchool of Medicine, Baylor College of Medicine, Houston, Texas, USA.
Katherine PromerDepartment of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, San Diego, California, USA.ORCID 0000-0002-5280-7629
Jesica HayonDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Roumen IordanovDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.
Khuzaima RangwallaSchool of Medicine, University of California, SanFrancisco, San Francisco, California, USA.
Jerry J ZhangSchool of Biological Sciences, University of California, Irvine, Irvine, California, USA.
Zian FangSchool of Biological Sciences, University of California, Irvine, Irvine, California, USA.
Cindy HuangSchool of Biological Sciences, University of California, Irvine, Irvine, California, USA.
Cassiana E BittencourtDepartment of Pathology, University of California, Irvine, Irvine, California, USA.
Sharon ReedDepartment of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego, San Diego, California, USA.ORCID 0000-0001-7615-9366
Rosa M AndradeDepartment of Medicine, Division of Infectious Diseases, University of California, Irvine, Irvine, California, USA.ORCID 0000-0002-8802-1118
Caryn BernDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.ORCID 0000-0001-8195-7303
Eva H ClarkDepartment of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0350-8753
Jeffrey D WhitmanDepartment of Laboratory Medicine, University of California, SanFrancisco, San Francisco, California, USA.ORCID 0000-0002-3502-5799
University of California, Irvine · USBaylor College of Medicine · USUniversity of California, San Francisco · USUniversity of California San Diego · US

Funding

Impact of intestinal helminth infection on HPV co-infection and the cervico-vaginal environment.K23AI168583 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI Eva H Clark · 2022 to 2026
$862k
NIAID NIH HHS K23 AI168583
6 · The paper itself

Abstract

backgroundChagas disease (CD) is a parasitic disease that affects ∼300 000 people living in the United States. CD leads to cardiac and/or gastrointestinal disease in up to 30% of untreated people. However, end-organ damage can be prevented with early diagnosis and antiparasitic therapy.

methodsWe reviewed electronic health records of patients who underwent testing for CD at four hospital systems in California and Texas between 2016 and 2020. Descriptive analyses were performed as a needs assessment for improving CD diagnosis.

resultsIn total, 470 patients were tested for CD. Cardiac indications made up more than half (60%) of all testing, and the most frequently cited cardiac condition was heart failure. Fewer than 1% of tests were ordered by obstetric and gynecologic services. Fewer than half (47%) of patients had confirmatory testing performed at the Centers for Disease Control and Prevention. DISCUSSION: Four major hospitals systems in California and Texas demonstrated low overall rates of CD diagnostic testing, testing primarily among older patients with end-organ damage, and incomplete confirmatory testing. This suggests missed opportunities to diagnose CD in at-risk individuals early in the course of infection when antiparasitic treatment can reduce the risk of disease progression and prevent vertical transmission.

Indexed as

Chagas DiseaseTrypanosoma cruziAntiparasitic AgentsCaliforniaFemaleHumansPregnancyTexasUnited StatesAntiparasitic AgentsChagas diseasediagnosisserologyTrypanosoma cruziUnited States

Identifiers

PMID37853514
PMCPMC11032249
OpenAlexW4387765360

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.