ArticleCommunications biology2023
Calpeptin is a potent cathepsin inhibitor and drug candidate for SARS-CoV-2 infections.
Open access · goldAbstract read
In one paragraph
Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- Assessment of the Binding Affinity of Covalent Inhibitors of Cruzain and Cathepsin L Using Relative Binding Free Energy.ChemMedChem · 2026Article
- Calpeptin Reduces Extracellular Vesicle Secretion and Induces Anti-Inflammatory Effects but Upregulates HO-1 and Alters Adiponectin Levels in Human Adipocytes.Journal of extracellular biology · 2026Article
- Exploring Key Regulators of Mitochondrial Dynamics and Immune Response in SARS-CoV-2 Infection.Viruses · 2026Article
- Calpain inhibition by calpeptin modulates adipocyte lipid metabolism and secretome-mediated inflammatory crosstalk with hepatocytes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Article
- Statistical crystallography reveals an allosteric network in SARS-CoV-2 MCommunications biology · 2026Article
- The synergistic interaction between ACE and TMPRSS2 polymorphisms increases the risk of severe COVID-19.PloS one · 2026Article
- Peptidomimetic Phenoxymethyl Ketone Warheads as Potent Dual-Mode Inhibitors against SARS-CoV-2 MJournal of medicinal chemistry · 2025Article
- Calcineurin inhibition may prevent Alzheimer disease in people with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.Journal of medicinal chemistry · 2024Article
- SARS-CoV-2 MNature communications · 2024Article
- Cathepsin-Targeting SARS-CoV-2 Inhibitors: Design, Synthesis, and Biological Activity.ACS pharmacology & translational science · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 10 institutions in 7 countries.
Patrick Y A Reinke *Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7354-0839
Edmarcia Elisa de Souza *Department of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil.
Sebastian Günther *Center for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-7329-6653
Sven FalkeCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0003-3409-1791
Julia LieskeCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-5439-5082
Wiebke EwertCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-8626-4864
Jure LobodaDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0002-9601-3484
Alexander HerrmannInstitute of Virology, Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-2749-9003
Aida Rahmani MashhourCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0001-9177-5589
Katarina KarničarDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0002-7033-9224
Aleksandra UsenikDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0003-2366-2886
Nataša LindičDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.ORCID http://orcid.org/0000-0001-7681-3436
Andreja SekirnikDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia.
Viviane Fongaro BotossoVirology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-7876-3687
Gláucia Maria Machado SantelliDepartment of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Josana KapronezaiVirology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-2182-4549
Marcelo Valdemir de AraújoVirology Laboratory, Center of Development and Innovation, Butantan Institute, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-9695-3225
Taiana Tainá Silva-PereiraDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Antônio Francisco de Souza FilhoDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0003-4728-1228
Mariana Silva TavaresDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Lizdany Flórez-ÁlvarezDepartment of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil.
Danielle Bruna Leal de OliveiraDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-0534-0886
Edison Luiz DurigonDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
Paula Roberta GiarettaGastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, 4474 TAMU, School Station, TX, USA.ORCID http://orcid.org/0000-0003-2261-281X
Marcos Bryan HeinemannDepartment of Preventive Veterinary Medicine and Animal Health, College of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0001-6444-9788
Maurice HauserInstitute for Organic Chemistry and BMWZ, Leibniz University of Hannover, Schneiderberg 38, 30167, Hannover, Germany.
Brandon SeychellDepartment of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.
Hendrik BöhlerDepartment of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.
Wioletta RutDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.
Marcin DragDepartment of Chemical Biology and Bioimaging, Faculty of Chemistry, Wrocław University of Science and Technology, Wybrzeże Wyspiańskiego 27, 50-370, Wrocław, Poland.ORCID http://orcid.org/0000-0001-8510-1967
Tobias BeckDepartment of Chemistry, Institute of Physical Chemistry, Universität Hamburg, Grindelallee 117, 20146, Hamburg, Germany.ORCID http://orcid.org/0000-0001-7398-3982
Russell CoxInstitute for Organic Chemistry and BMWZ, Leibniz University of Hannover, Schneiderberg 38, 30167, Hannover, Germany.ORCID http://orcid.org/0000-0002-1844-0157
Henry N ChapmanCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.ORCID http://orcid.org/0000-0002-4655-1743
Christian BetzelHamburg Centre for Ultrafast Imaging, Universität Hamburg, Luruper Chaussee 149, 22761, Hamburg, Germany.ORCID http://orcid.org/0000-0002-3879-5019
Wolfgang BrehmCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany.
Winfried HinrichsUniversität Greifswald, Institute of Biochemistry, Felix-Hausdorff-Str. 4, 17489, Greifswald, Germany.ORCID http://orcid.org/0000-0002-0435-4565
Gregor EbertInstitute of Virology, Helmholtz Munich, Munich, Germany.ORCID http://orcid.org/0000-0002-5318-3037
Sharissa L LathamThe Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Ana Marcia de Sá GuimarãesDepartment of Microbiology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.ORCID http://orcid.org/0000-0002-8261-5863
Dusan TurkDepartment of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Jamova 39, 1000, Ljubljana, Slovenia. dusan.turk@ijs.si.ORCID http://orcid.org/0000-0003-0205-6609
Carsten WrengerDepartment of Parasitology, Institute of Biomedical Sciences at the University of São Paulo, São Paulo, Brazil. cwrenger@icb.usp.br.ORCID http://orcid.org/0000-0001-5987-1749
Alke MeentsCenter for Free-Electron Laser Science CFEL, Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607, Hamburg, Germany. alke.meents@desy.de.ORCID http://orcid.org/0000-0001-6078-4095
Universität Hamburg · DEUniversidade de São Paulo · BRJožef Stefan Institute · SIHelmholtz Zentrum München · DEInstituto Butantan · BRLeibniz University Hannover · DEWrocław University of Science and Technology · PLGarvan Institute of Medical Research · AUTexas A&M University · USUniversität Greifswald · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (M
Indexed as
COVID-19Antiviral AgentsCathepsinsCysteine EndopeptidasesDipeptidesHumansProtease InhibitorsSARS-CoV-2Antiviral AgentscalpeptinCathepsinsCysteine EndopeptidasesDipeptidesProtease Inhibitors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.