Evidence map›Paper›PMID 37853163›Full record

Trial reportPediatric cardiology2024

The Impact of Nasal Intubation on Feeding Outcomes in Neonates Requiring Cardiac Surgery: A Randomized Control Trial.

Melissa I Yildirim, Michael C Spaeder, Barbara A Castro, Rebecca Chamberlain, Lisa Fuzy, Sarah Howard, Peggy McNaull, Jacob Raphael, Ruchik Sharma, Samantha Vizzini and 2 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Pediatric cardiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378685 (The Effect of Oral Versus Nasal Intubation on Feeding Outcomes in Neonates Requiring Cardiac Surgery), which is not on this map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05378685 naunknown statusnot on this map

The Effect of Oral Versus Nasal Intubation on Feeding Outcomes in Neonates Requiring Cardiac Surgery

TypeinterventionalSponsorUniversity of VirginiaRan2018 to 2022Enrolled80ConditionsCongenital Heart Disease, Oral AversionArmsEndotracheal intubation
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Comparison of Unplanned Extubations Associated with Orotracheal versus Nasotracheal Intubation in Infants.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Melissa I YildirimDivision of Pediatric Cardiology, Department of Pediatrics, Cleveland Clinic Children's Hospital, Cleveland, OH, USA. yildirm@ccf.org.
Michael C SpaederDivision of Pediatric Critical Care, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.
Barbara A CastroDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Rebecca ChamberlainDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.
Lisa FuzyDivision of Thoracic and Cardiovascular Surgery, Department of Surgery, University of Virginia School of Medicine, Charlottesville, VA, USA.
Sarah HowardDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Peggy McNaullDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Jacob RaphaelDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Ruchik SharmaDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Samantha VizziniDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Amy WielarDivision of Pediatric Anesthesiology, Department of Anesthesiology, University of Virginia School of Medicine, Charlottesville, VA, USA.
Deborah U FrankDivision of Pediatric Critical Care, Department of Pediatrics, University of Virginia School of Medicine, Charlottesville, VA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neonates who require surgery for congenital heart disease (CHD) frequently have difficulty with oral feeds post-operatively and may require a feeding tube at hospital discharge. The purpose of this study was to determine the effect of oral or nasal intubation route on feeding method at hospital discharge. This was a non-blinded randomized control trial of 62 neonates who underwent surgery for CHD between 2018 and 2021. Infants in the nasal (25 patients) and oral (37 patients) groups were similar in terms of pre-operative risk factors for feeding difficulties including completed weeks of gestational age at birth (39 vs 38 weeks), birthweight (3530 vs 3100 g), pre-operative PO intake (92% vs 81%), and rate of pre-operative intubation (22% vs 28%). Surgical risk factors were also similar including Society of Thoracic Surgeons-European Association for Cardio-Thoracic Surgery category (3.9 vs 4.1), shunt placement (32% vs 41%), cardiopulmonary bypass time (181 vs 177 min), and cross-clamp time (111 vs 105 min). 96% of nasally intubated patients took full oral feeds by discharge as compared with 78% of orally intubated infants (p = 0.05). Nasally intubated infants reach full oral feeds an average of 3 days earlier than their orally intubated peers. In this cohort of patients, nasally intubated infants reach oral feeds more quickly and are less likely to require supplemental tube feeding in comparison to orally intubated peers. Intubation route is a potential modifiable risk factor for oral aversion and appears safe in neonates. The study was approved by the University of Virginia Institutional Review Board for Health Sciences Research and was retrospectively registered on clinicaltrials.gov (NCT05378685) on May 18, 2022.

Indexed as

Cardiac Surgical ProceduresHeart Defects, CongenitalThoracic SurgeryEnteral NutritionHumansInfantInfant, NewbornIntubation, GastrointestinalCongenitalCongenital heart disease outcomesCritical care outcomesEnteral nutritionGastrostomyHeart defectsIntubationSupplementary feeding

Identifiers

PMID37853163

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.