ArticleNature2023
Macromolecular condensation buffers intracellular water potential.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 77 papers.
0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed
22.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
77 citing papers in PubMed, 143 citations in OpenAlex.
- Miscompartmentalization of microbiota-derived TMAO is a reversible driver in autism spectrum disorder.iScience · 2026Article
- Biomolecular condensates in plant stress and development: recent advances and emerging concepts.Journal of experimental botany · 2026Review
- Liquid-Liquid Phase Separation-Enhanced Multienzyme Catalysis: Mechanisms and Applications.ChemSusChem · 2026Review
- Seeing the Chemistry of Biomolecular Condensates: In Situ Mapping of Composition and Water Content.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Phase separation across membranes and condensates in cell organization and function.Nature reviews. Molecular cell biology · 2026Review
- Biomolecular condensates mediate C-N bond formation.Nature chemical biology · 2026Article
- Article
- Article
- Short autoinhibitory sequences control phase separation of an essential bacterial transcription termination factor.The EMBO journal · 2026Article
- 2'-O-Methylation maintains ribosome structural and translation integrity.Molecular cell · 2026Article
- Rapid photo-crosslinking in living cells reveals protein-nucleic acid dynamics on a timescale of minutes.Nucleic acids research · 2026Article
- Electrogenic protein condensates as intracellular electrochemical reactors.Nature materials · 2026Article
- Asymmetry in Hydrophobicity Induces Electric Potential in Non-Charged Biomolecular Condensates.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Fluorescence-based mapping of condensate dielectric permittivity uncovers hydrophobicity-driven membrane interactions.Nature communications · 2026Article
- Dynamic Covalent Boronate Chemistry forJournal of the American Chemical Society · 2026Article
- Single-engineered-residue solvation perturbations regulate global protein architecture and function.Nature communications · 2026Article
- A cellular basis for the mammalian nocturnal-diurnal switch.Science (New York, N.Y.) · 2026Article
- A Site-Specific Self-Association of a Protein Hub Drives Its Phase Separation.ACS chemical biology · 2026Article
- How does cytoplasmic crowding affect reaction rates?Molecular cell · 2026Review
- Rapid activation of p62 body-mediated autophagy in human cells under hyperosmotic stress.Communications biology · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
31 authors at 7 institutions in 3 countries.
Joseph L WatsonMRC Laboratory of Molecular Biology, Cambridge, UK.
Estere Seinkmane *MRC Laboratory of Molecular Biology, Cambridge, UK.
Christine T Styles *Department of Infectious Disease, Imperial College London, London, UK.
Andrei MihutMRC Laboratory of Molecular Biology, Cambridge, UK.
Lara K KrügerMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-0439-951X
Kerrie E McNallyMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-2376-3003
Vicente Jose Planelles-HerreroMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-1665-184X
Michal DudekWellcome Centre for Cell Matrix Research, University of Manchester, Manchester, UK.ORCID 0000-0003-3152-1127
Patrick M McCallCluster of Excellence Physics of Life, TU Dresden, Dresden, Germany.
Silvia BarbieroMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0001-7177-6947
Michael Vanden OeverDepartment of Infectious Disease, Imperial College London, London, UK.
Sew Yeu Peak-ChewMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-7602-6384
Benjamin T PorebskiMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-1398-0442
Aiwei ZengMRC Laboratory of Molecular Biology, Cambridge, UK.
Nina M RzechorzekMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-3209-5019
David C S WongMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-1712-9527
Andrew D BealeMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0002-2051-0919
Alessandra StangherlinMRC Laboratory of Molecular Biology, Cambridge, UK.
Margot RiggiDepartment of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Janet IwasaDepartment of Biochemistry, University of Utah, Salt Lake City, UT, USA.
Jörg MorfLaboratory of Nuclear Dynamics, Babraham Institute, Cambridge, UK.ORCID 0000-0002-0485-3380
Christos MiliotisLaboratory of Nuclear Dynamics, Babraham Institute, Cambridge, UK.
Alina GunaCalifornia Institute of Technology, Pasadena, CA, USA.
Alison J InglisCalifornia Institute of Technology, Pasadena, CA, USA.
Jan BruguésCluster of Excellence Physics of Life, TU Dresden, Dresden, Germany.ORCID 0000-0002-6731-4130
Rebecca M VoorheesCalifornia Institute of Technology, Pasadena, CA, USA.
Joseph E ChambersCambridge Institute for Medical Research, Cambridge, UK.ORCID 0000-0003-4675-0053
Qing-Jun MengWellcome Centre for Cell Matrix Research, University of Manchester, Manchester, UK.ORCID 0000-0002-9426-8336
John S O'NeillMRC Laboratory of Molecular Biology, Cambridge, UK. oneillj@mrc-lmb.cam.ac.uk.ORCID 0000-0003-2204-6096
Rachel S EdgarDepartment of Infectious Disease, Imperial College London, London, UK. rachel.edgar@imperial.ac.uk.ORCID 0000-0002-3348-0851
Emmanuel DeriveryMRC Laboratory of Molecular Biology, Cambridge, UK. derivery@mrc-lmb.cam.ac.uk.ORCID 0000-0003-3927-5944
MRC Laboratory of Molecular Biology · GBCalifornia Institute of Technology · USImperial College London · GBBabraham Institute · GBMax Planck Institute for the Physics of Complex Systems · DEUniversity of Utah · USWellcome Centre for Cell-Matrix Research · GB
Funding
Medical Research Council MC_EX_MR/S022023/1Medical Research Council MC_UP_1201/13Medical Research Council MC_UP_1201/4Medical Research Council MR/K019392/1Medical Research Council MR/V028669/1Wellcome Trust
Abstract
Optimum protein function and biochemical activity critically depends on water availability because solvent thermodynamics drive protein folding and macromolecular interactions
Indexed as
Macromolecular SubstancesProteinsSolventsThermodynamicsWaterCell DeathCytosolHomeostasisOsmolar ConcentrationPressureTemperatureTime FactorsMacromolecular SubstancesProteinsSolventsWater
Identifiers
What OpenQuestion holds
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Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.