Evidence map›Paper›PMID 37853086›Full record

Trial reportScientific reports2023

High-frequency ultrasound in anti-aging skin therapy monitoring.

Joanna Czajkowska, Jan Juszczyk, Monika Natalia Bugdol, Małgorzata Glenc-Ambroży, Anna Polak, Laura Piejko, Ewa Pietka

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
9.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Review
  4. Ultrasound of the Cheek: Examination Technique, Anatomy, and Abnormal Findings.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Chemical Biostimulation of Labial Majora: First Clinical Insights.Clinical, cosmetic and investigational dermatology · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Joanna CzajkowskaFaculty of Biomedical Engineering, Silesian University of Technology, 41-800, Zabrze, Poland. joanna.czajkowska@polsl.pl.
Jan JuszczykFaculty of Biomedical Engineering, Silesian University of Technology, 41-800, Zabrze, Poland.
Monika Natalia BugdolFaculty of Biomedical Engineering, Silesian University of Technology, 41-800, Zabrze, Poland.
Małgorzata Glenc-AmbrożyAmber Academy Research Center, 44-200, Rybnik, Poland.
Anna PolakJerzy Kukuczka Academy of Physical Education, Institute of Physiotherapy and Health Sciences, 40-065, Katowice, Poland.
Laura PiejkoJerzy Kukuczka Academy of Physical Education, Institute of Physiotherapy and Health Sciences, 40-065, Katowice, Poland.
Ewa PietkaFaculty of Biomedical Engineering, Silesian University of Technology, 41-800, Zabrze, Poland.
Silesian University of Technology · PLAkademii Wychowania Fizycznego im. Jerzego Kukuczki w Katowicach · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the last few decades, high-frequency ultrasound has found multiple applications in various diagnostic fields. The fast development of this imaging technique opens up new diagnostic paths in dermatology, allergology, cosmetology, and aesthetic medicine. In this paper, being the first in this area, we discuss the usability of HFUS in anti-aging skin therapy assessment. The fully automated algorithm combining high-quality image selection and entry echo layer segmentation steps followed by the dermal parameters estimation enables qualitative and quantitative evaluation of the effectiveness of anti-aging products. Considering the parameters of subcutaneous layers, the proposed framework provides a reliable tool for TCA-peel therapy assessment; however, it can be successfully applied to other skin-condition-related problems. In this randomized controlled clinical trial, forty-six postmenopausal women were randomly assigned to the experimental and control groups. Women were treated four times at one-week intervals and applied skin cream daily between visits. The three month follow-up study enables measurement of the long-term effect of the therapy. According to the results, the TCA-based therapy increased epidermal (entry echo layer) thickness, indicating that the thinning process has slowed down and the skin's condition has improved. An interesting outcome is the obtained growth in the intensity of the upper dermis in the experimental group, which might suggest a reduced photo-aging effect of TCA-peel and increased water content. The same conclusions connected with the anti-aging effect of TCA-peel can be drawn by observing the parameters describing the contribution of low and medium-intensity pixels in the upper dermis. The decreased share of low-intensity pixels and increased share of medium-intensity pixels in the upper dermis suggest a significant increase in local protein synthesis.

Indexed as

Skin AgingAgingEpidermisFemaleFollow-Up StudiesHumansSkinUltrasonography

Identifiers

PMID37853086
PMCPMC10584894
OpenAlexW4387745035

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.