Evidence map›Paper›PMID 37853083›Full record

ArticleScientific reports2023

Human thymic putative CD8αα precursors exhibit a biased TCR repertoire in single cell AIRR-seq.

Marte Heimli, Siri Tennebø Flåm, Hanne Sagsveen Hjorthaug, Pål Marius Bjørnstad, Maria Chernigovskaya, Quy Khang Le, Xavier Tekpli, Victor Greiff, Benedicte Alexandra Lie

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marte HeimliDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Siri Tennebø FlåmDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Hanne Sagsveen HjorthaugDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Pål Marius BjørnstadDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Maria ChernigovskayaDepartment of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Quy Khang LeDepartment of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Xavier TekpliDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway.
Victor GreiffDepartment of Immunology, University of Oslo and Oslo University Hospital, 0372, Oslo, Norway.
Benedicte Alexandra LieDepartment of Medical Genetics, University of Oslo and Oslo University Hospital, 0424, Oslo, Norway. b.a.lie@medisin.uio.no.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

Wellcome Trust 214280
6 · The paper itself

Abstract

Thymic T cell development comprises T cell receptor (TCR) recombination and assessment of TCR avidity towards self-peptide-MHC complexes presented by antigen-presenting cells. Self-reactivity may lead to negative selection, or to agonist selection and differentiation into unconventional lineages such as regulatory T cells and CD8[Formula: see text] T cells. To explore the effect of the adaptive immune receptor repertoire on thymocyte developmental decisions, we performed single cell adaptive immune receptor repertoire sequencing (scAIRR-seq) of thymocytes from human young paediatric thymi and blood. Thymic PDCD1

Indexed as

Receptors, Antigen, T-CellThymocytesCell DifferentiationChildComplementarity Determining RegionsHumansReceptors, Antigen, T-Cell, alpha-betaThymus GlandT-Lymphocytes, RegulatoryComplementarity Determining RegionsReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID37853083
PMCPMC10584817
OpenAlexW4387739893

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.