ArticleScientific reports2023
Correlation analysis of obesity phenotypes with leptin and adiponectin.
Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Regular collagen peptide administration exerts anti-obesity effects in high-caloric diet-fed rodents-a systematic review with meta-analysis of animal trials.International journal of obesity (2005) · 2026Pooled it
- Evaluation of Serum Irisin, Leptin, Adiponectin, Resistin, and Galectin-3 Levels and Their Relationship with Ultrasonographic Subcutaneous Fat Thickness in Patients with Lipedema.Aesthetic plastic surgery · 2026Article
- Different association of GDF15 and FGF21 with glycemic status and aging in the context of obesity.GeroScience · 2026Article
- Adipose-inflammatory factor profiles in children with metabolically healthy obesity and their correlation with NAFLD severity.Frontiers in pediatrics · 2026Article
- Multidimensional Analysis of Serum Adiponectin, Leptin, and Resistin Levels and Their Correlation with Childhood Obesity Based on Gut Microbiota and Inflammatory Markers: A Single-Center Cross-Sectional Retrospective Study.International journal of general medicine · 2026Article
- Leptin-Independent Association Between SNVs in the Leptin Gene and HDL-C and Apo-AI in Children.International journal of molecular sciences · 2025Article
- Assessment of the Risk of Insulin Resistance in Workers Classified as Metabolically Healthy Obese.Nutrients · 2025Article
- Adipocytokine Protein Expression from Visceral Fat Differs Significantly Based on Diet, Sex, and Age in C3H/HeJ Mice Fed Long-Term, High-Fat Diets, ± Ammonium-Hydroxide-Supplemented Dietary Protein.Current issues in molecular biology · 2025Article
- Efficacy of Fetal Wharton's Jelly Mesenchymal Stem Cells-Derived Small Extracellular Vesicles in Metabolic Syndrome.Biomolecules · 2025Article
- Relationship between physical activity and abdominal obesity and metabolic markers in postmenopausal women.Scientific reports · 2024Article
- Article
- AMP-activated protein kinase activation suppresses leptin expression independently of adipogenesis in primary murine adipocytes.The Biochemical journal · 2024Article
- Surrogate indices of insulin resistance using the Matsuda index as reference in adult men-a computational approach.Frontiers in endocrinology · 2024Article
- The Therapeutic Effectiveness of Laparoscopic Sleeve Gastrectomy Among Individuals with Low BMI Obesity (30-35 Kg/mInternational journal of general medicine · 2024Article
- Obesity and leptin in breast cancer angiogenesis.Frontiers in endocrinology · 2024Review
- Cerebrospinal fluid Visinin-like protein-1 was associated with the relationship of body mass index with Alzheimer's disease pathology and cognition in non-demented elderly.Journal of Alzheimer's disease reportsArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity can be categorized as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO). However, individuals with MHO are characterized by the absence of metabolic syndrome (MS) and appear to have lower inflammation levels compared to MUO. This study aimed to investigate the association of obesity phenotypes with leptin (LEP) and adiponectin (ADP). According to the inclusion and exclusion criteria, we selected 178 subjects from the previous cross-sectional survey. Based on the body mass index (BMI) and diagnostic criteria of MS, we divided the individuals into three groups, including healthy control group (HC group), metabolically healthy obesity group (MHO group) and metabolically unhealthy obesity group (MUO group). The concentrations of LEP and ADP in serum were measured, and the association of these two cytokines with different obesity phenotypes were subsequently analyzed. Compared to both the HC and MHO groups, the MUO group showed significantly higher BMI, waist circumference (WC), waist-hip ratio (WHR), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), fasting plasma glucose (FPG), homeostasis model assessment of insulin resistance (Homa-IR) and blood pressure (P < 0.05). In contrast, serum high-density lipoprotein cholesterol (HDL-C) was notably lower in the MUO group (P < 0.05). ADP was found to have a positive correlation with systolic blood pressure (SBP) and a negative correlation with FPG in the MHO group. In the MUO group, LEP demonstrated a positive correlation with fasting insulin (FINS) and Homa-IR, while ADP showed a positive correlation with TC and SBP. Linear regression analysis further indicated that SBP (β = 0.234, P = 0.043), TG (β = - 0.292, P = 0.001) and LDL-C (β = 0.626, P = 0.000) were independently correlated with ADP, and BMI (β = 0.398, P = 0.002) was independently correlated with LEP in obese individuals. In conclusion, ADP and LEP were closely related with glucose and lipid metabolism in obese individuals, these two cytokines might play critical roles in obesity-associated metabolic disorders.
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