ArticleJournal of neurointerventional surgery2024
In vitro and in silico assessment of flow modulation after deploying the Contour Neurovascular System in intracranial aneurysm models.
Article in Journal of neurointerventional surgery, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Clinical outcome prediction of Contour Neurovascular System treatment based on pre-treatment geometric and hemodynamic characteristics.International journal of computer assisted radiology and surgery · 2026Article
- Hemodynamic Impact of Morphological Changes in Intracranial Aneurysms Treated with the Contour Neurovascular System: A Pilot In Silico Study.Brain sciences · 2026Article
- Evaluating flow modulating treatment response in intracranial aneurysms using black-blood MRI in vitro.Communications medicine · 2026Article
- Embolization of Ruptured and Unruptured Aneurysms with the Contour Neurovascular System-Summary of 106 Cases.AJNR. American journal of neuroradiology · 2025Article
- Assessment of intracranial aneurysm neck deformation after contour deployment.International journal of computer assisted radiology and surgery · 2024Article
- Multi-Dimensional Modeling of Cerebral Hemodynamics: A Systematic Review.Bioengineering (Basel, Switzerland) · 2024Review
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe novel Contour Neurovascular System (Contour) has been reported to be efficient and safe for the treatment of intracranial, wide-necked bifurcation aneurysms. Flow in the aneurysm and posterior cerebral arteries (PCAs) after Contour deployment has not been analyzed in detail yet. However, this information is crucial for predicting aneurysm treatment outcomes.
methodsTime-resolved three-dimensional velocity maps in 14 combinations of patient-based basilar tip aneurysm models with and without Contour devices (sizes between 5 and 14 mm) were analyzed using four-dimensionsal (4D) flow MRI and numerical/image-based flow simulations. A complex virtual processing pipeline was developed to mimic the experimental shape and position of the Contour together with the simulations.
resultsOn average, the Contour significantly reduced intra-aneurysmal flow velocity by 67% (mean w/ = 0.03m/s; mean w/o = 0.12m/s; p-value=0.002), and the time-averaged wall shear stress by more than 87% (mean w/ = 0.17Pa; mean w/o = 1.35Pa; p-value=0.002), as observed by numerical simulations. Furthermore, a significant reduction in flow (P<0.01) was confirmed by the neck inflow rate, kinetic energy, and inflow concentration index after Contour deployment. Notably, device size has a stronger effect on reducing flow than device positioning. However, positioning affected flow in the PCAs, while being robust in effectively reducing flow.
conclusionsThis study showed the high efficacy of the Contour device in reducing flow within aneurysms regardless of the exact position. However, we observed an effect on the flow in PCAs, which needs to be investigated further.
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