Evidence map›Paper›PMID 37852742›Full record

ArticleThe British journal of ophthalmology2024

Ocular blood flow biomarkers may predict long-term glaucoma progression.

Alice Chandra Verticchio Vercellin, Alon Harris, Francesco Oddone, Brent Siesky, George Eckert, Aditya Belamkar, Gal Antman, Fani Segev

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The British journal of ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01145911 (The Study of Ocular Hemodynamics With Glaucoma Progression), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01145911 completednot on this map

The Study of Ocular Hemodynamics With Glaucoma Progression

TypeobservationalSponsorIndiana UniversityRan2008 to 2014Enrolled123ConditionsGlaucoma
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. The Effect of Carotid Atherosclerosis on the Risk for Open-Angle Glaucoma.Investigative ophthalmology & visual science · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 3 countries.

Alice Chandra Verticchio VercellinOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Alon HarrisOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA palonharris@gmail.com.ORCID 0000-0001-8770-3726
Francesco OddoneGlaucoma Unit, IRCCS Fondazione G.B.Bietti, Rome, Italy.
Brent SieskyOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
George EckertDepartment of Biostatistics abd Health Data Science, Indiana University School of Medicine and Richard M. Fairbanks School of Public Health, Indianapolis, Indiana, USA.
Aditya BelamkarOphthalmology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Gal AntmanOphthalmology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Fani SegevOphthalmology, Assuta Ashdod Medical Center, Goldman Medical School, Ben-Gurion University, Be'er Sheva, Israel.
Icahn School of Medicine at Mount Sinai · USIndiana University School of MedicineAssuta Medical Center · ILFondazione G.B. Bietti · ITMount Sinai Hospital · USRabin Medical Center · IL

Funding

Integration of clinical measures and theoretical modeling to quantify sectorial specific changes in ocular structure, function, and hemodynamicsR01EY030851 · NEI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ARCIERO, JULIA, HARRIS, ALON · 2020 to 2023
$1.3M
SCH: SEEthroughGLAUCOMA: Smart Eye Emulator (SEE) to study glaucoma risk factorsR01EY034718 · NEI · UNIVERSITY OF MAINE ORONO · PI GUIDOBONI, GIOVANNA, HARRIS, ALON · 2022 to 2025
$975k
NEI NIH HHS R01 EY030851NEI NIH HHS R01 EY034718
6 · The paper itself

Abstract

BACKGROUND/

aimTo examine the relationship between baseline blood flow biomarkers and long-term open-angle glaucoma (OAG) progression.

methods112 patients with early to moderate OAG (mean age 64.9±11.0 years; 68 female) were evaluated at baseline and every 6 months from 2008 to 2013. Biomarkers of retinal capillary blood flow were assessed by Heidelberg retinal flowmetry. Functional disease progression was monitored via Humphrey visual field examinations, defined as two consecutive visits with a mean deviation decrease ≥2 decibels and/or Advanced Glaucoma Intervention Study score increase ≥2 compared with baseline. Structural progression was monitored with optical coherence tomography and Heidelberg retinal tomograph, defined as two consecutive visits with retinal nerve fibre layer thickness decrease ≥8% and/or horizontal or vertical cup/disk ratio increase ≥0.2 compared with baseline. Mixed-model analysis of covariance was used to test for significant change from baseline to 5-year follow-up. Times to functional and structural progression were analysed using Cox proportional hazards models.

resultsLower HRF retinal capillary blood flow in the superior retina was significantly associated with structural progression (p=0.0009).

conclusionIn our OAG sample, baseline lower retinal capillary perfusion in the superior retina was predictive of structural progression after 5 years. TRIAL REGISTRATION NUMBER: NCT01145911.

Indexed as

BiomarkersDisease ProgressionGlaucoma, Open-AngleIntraocular PressureRegional Blood FlowRetinal VesselsTomography, Optical CoherenceVisual FieldsAgedBlood Flow VelocityCapillariesFemaleFollow-Up StudiesHumansLaser-Doppler FlowmetryMaleBiomarkersGlaucomaImagingOptic Nerve

Identifiers

PMID37852742
PMCPMC12333459
OpenAlexW4387737690

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.