Trial reportBMJ (Clinical research ed.)2023
Clinical effectiveness of septoplasty versus medical management for nasal airways obstruction: multicentre, open label, randomised controlled trial.
Trial report in BMJ (Clinical research ed.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06731881 (Leveraging Photodynamic Therapy to Inhibit Microorganisms - Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections in Nasal Surgery Patients), which is not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Leveraging Photodynamic Therapy to Inhibit Microorganisms - Assessing the Efficacy of Photodynamic Therapy for Preventing Surgical Site Infections in Nasal Surgery Patients: A Pilot Study
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Patient and public involvement and engagement (PPIE) in Otolaryngology research: a systematic review of randomised controlled trials.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025Pooled it
- Trial
- Exploring the Relationships Between Clinical Examination Findings, Subjective Reported Symptoms and Objective Nasal Patency Measures in Nasal Obstruction: A Baseline NAIROS Sub-Study Analysis.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2025Trial
- Safety and Effectiveness of a Bioabsorbable Septal Implant for Cartilaginous Nasal Septal Deviation.Laryngoscope investigative otolaryngology · 2026Article
- The Effect of Septoplasty and Inferior Turbinate Reduction on Measures of Exercise Capacity.The Laryngoscope · 2026Article
- The effectiveness of nonsurgical nasal devices in relieving nasal obstruction.Annals of the Royal College of Surgeons of England · 2026Article
- Septoplasty Versus Non-Surgical Treatment for Deviated Nasal Septum: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- Beyond the airway: the impact of septoplasty and turbinate reduction on somnolence and sleep disordered breathing risk-a prospective study.Frontiers in surgery · 2026Article
- Prevalence and Associated Factors of Olfactory and Gustatory Loss in Patients With Nasal Septal Deviation.Clinical otolaryngology : official journal of ENT-UK ; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery · 2026Article
- The State of the Art in Septoplasty: A Review of the Latest Achievements.BioMed research international · 2026Review
- Clinical Practice and Outcome of Septoplasty-A Retrospective Study of 11,714 Surgeries in Sweden 2014-2023.Laryngoscope investigative otolaryngology · 2025Article
- Article
- Persistent postseptoplasty nasal neuropathic pain.Pain reports · 2025Article
- Effectiveness of Septal Swell Body Reduction for Patients With Nasal Airway Obstruction: A Systematic Review and Meta-Analysis.Clinical and experimental otorhinolaryngology · 2025Article
- Septoplasty-mediated improvements in nasal patency and pulmonary function: A prospective study.Laryngoscope investigative otolaryngology · 2025Article
- Quality of Life of Patients After Nasal Septoplasty.Materia socio-medica · 2025Article
- Article
- Evolving Trends and Future Demands in ENT Procedures: A Nationwide 10-Year Analysis.Journal of clinical medicine · 2024Article
- Article
Corrections and comments
- Commented on by
Authors and funding
28 authors at 10 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the clinical effectiveness of septoplasty.
designMulticentre, randomised controlled trial.
setting17 otolaryngology clinics in the UK's National Health Service.
participants378 adults (≥18 years, 67% men) newly referred with symptoms of nasal obstruction associated with septal deviation and at least moderate symptoms of nasal obstruction (score >30 on the Nasal Obstruction and Symptom Evaluation (NOSE) scale).
interventionsParticipants were randomised 1:1 to receive either septoplasty (n=188) or defined medical management (n=190, nasal steroid and saline spray for six months), stratified by baseline symptom severity and sex.
main outcome measuresThe primary outcome measure was patient reported score on the Sino-Nasal Outcome Test-22 (SNOT-22) at six months, with 9 points defined as the minimal clinically important difference. Secondary outcomes included quality of life and objective nasal airflow measures.
resultsMean SNOT-22 scores at six months were 19.9 (95% confidence interval 17.0 to 22.7) in the septoplasty arm (n=152, intention-to-treat population) and 39.5 (36.1 to 42.9) in the medical management arm (n=155); an estimated 20.0 points lower (better) for participants randomised to receive septoplasty (95% confidence interval 16.4 to 23.6, P<0.001, adjusted for baseline continuous SNOT-22 score and the stratification variables sex and baseline NOSE severity categories). Greater improvement in SNOT-22 scores was predicted by higher baseline symptom severity scores. Quality of life outcomes and nasal airflow measures (including peak nasal inspiratory flow and absolute inhalational nasal partitioning ratio) improved more in participants in the septoplasty group. Readmission to hospital with bleeding after septoplasty occurred in seven participants (4% of 174 who had septoplasty), and a further 20 participants (12%) required antibiotics for infections.
conclusionsSeptoplasty is a more effective intervention than a defined medical management regimen with a nasal steroid and saline spray in adults with nasal obstruction associated with a deviated nasal septum.
trial registrationISRCTN Registry ISRCTN16168569.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.