Evidence map›Paper›PMID 37852546›Full record

ArticleFree radical biology & medicine2023

Extracellular SOD modulates canonical TNFα signaling and α5β1 integrin transactivation in vascular smooth muscle cells.

Hyehun Choi, Michael R Miller, Hong-Ngan Nguyen, Victoria E Surratt, Stephen R Koch, Ryan J Stark, Fred S Lamb

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Free radical biology & medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Hyehun ChoiDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA. Electronic address: hyehun.choi@vumc.org.
Michael R MillerDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Hong-Ngan NguyenDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Victoria E SurrattDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Stephen R KochDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Ryan J StarkDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Fred S LambDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, 37232, USA.
Vanderbilt University Medical Center · US

Funding

Anion channel regulation of vascular superoxide signaling in hypertensionR01HL160975 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LAMB, FRED S · 2022 to 2025
$2.9M
LRRC8 anion channels, superoxide and RhoA in diabetic erectile dysfunctionR01DK132948 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI LAMB, FRED S, WEBB, R CLINTON · 2022 to 2025
$2.7M
Mechanisms of vascular dysfunction in acute systemic inflammationR35GM138191 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STARK, RYAN J · 2020 to 2024
$2.2M
NHLBI NIH HHS R01 HL160975NIDDK NIH HHS R01 DK132948NIGMS NIH HHS R35 GM138191
6 · The paper itself

Abstract

TNFα activates NADPH oxidase 1 (Nox1) in vascular smooth muscle cells (VSMCs). The extracellular superoxide anion (O

Indexed as

Muscle, Smooth, VascularTumor Necrosis Factor-alphaAnimalsHydrogen PeroxideIntegrinsMiceNF-kappa BSignal TransductionSuperoxide DismutaseTranscriptional ActivationHydrogen PeroxideIntegrinsNF-kappa BSuperoxide DismutaseTumor Necrosis Factor-alphaAlpha5Beta1 integrinExtracellular superoxide dismutaseFibulin 5Superoxide dismutase 3Tumor necrosis factor-α

Identifiers

PMID37852546
PMCPMC10841345
OpenAlexW4387675763

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.