Evidence map›Paper›PMID 37852181›Full record

ArticleCell reports. Medicine2023

Systems serology in cystic fibrosis: Anti-Pseudomonas IgG1 responses and reduced lung function.

Shiping Lu, Kong Chen, Kejing Song, Joseph M Pilewski, Bronwyn M Gunn, Katie R Poch, Noel M Rysavy, Brian E Vestal, Milene T Saavedra, Jay K Kolls

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Genetic mutations enhance the production of Exotoxin A byExperimental and therapeutic medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Shiping LuDepartment of Immunology and Microbiology, Tulane University, New Orleans, LA, USA; Center for Translational Research in Infection and Inflammation, School of Medicine, Tulane University, New Orleans, LA, USA.
Kong ChenDivision of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Kejing SongCenter for Translational Research in Infection and Inflammation, School of Medicine, Tulane University, New Orleans, LA, USA.
Joseph M PilewskiDivision of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Bronwyn M GunnPaul G. Allen School of Global Health, Washington State University, Pullman, WA, USA.
Katie R PochNational Jewish Health, Denver, CO, USA.
Noel M RysavyNational Jewish Health, Denver, CO, USA.
Brian E VestalCenter for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.
Milene T SaavedraNational Jewish Health, Denver, CO, USA.
Jay K KollsCenter for Translational Research in Infection and Inflammation, School of Medicine, Tulane University, New Orleans, LA, USA. Electronic address: jkolls1@tulane.edu.
National Jewish Health · USTulane University · USUniversity of Pittsburgh · USWashington State University · US

Funding

Training in CD4 T-cell Lung ImmunityR35HL139930 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI KOLLS, JAY K · 2018 to 2024
$6.3M
NHLBI NIH HHS R35 HL139930
6 · The paper itself

Abstract

Nearly one-half of patients with cystic fibrosis (CF) carry the homozygous F508del mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene but exhibit variable lung function phenotypes. How adaptive immunity influences their lung function remains unclear, particularly the serological antibody responses to antigens from mucoid Pseudomonas in sera from patients with CF with varying lung function. Sera from patients with CF with reduced lung function show higher anti-outer membrane protein I (OprI) immunoglobulin G1 (IgG1) titers and greater antibody-mediated complement deposition. Induction of anti-OprI antibody isotypes with complement activity enhances lung inflammation in preclinical mouse models. This enhanced inflammation is absent in immunized Rag2

Indexed as

Cystic FibrosisAnimalsHumansImmunoglobulin GLungMicePseudomonasPseudomonas aeruginosaImmunoglobulin Gcomplement depositioncystic fibrosisimmunization-enhanced pathologylung inflammationPseudomonas aeruginosasystem serology

Identifiers

PMID37852181
PMCPMC10591031
OpenAlexW4387709161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.