Evidence map›Paper›PMID 37852041›Full record

ArticleCortex; a journal devoted to the study of the nervous system and behavior2023

Inability to move one's face dampens facial expression perception.

Shruti Japee, Jessica Jordan, Judith Licht, Savannah Lokey, Moebius Syndrome Research Consortium, Gang Chen, Joseph Snow, Ethylin Wang Jabs, Bryn D Webb, Elizabeth C Engle and 3 more

Open access · greenAbstract read
In one paragraph

Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Facial palsy reveals the sensorimotor contribution to facial-emotion recognition.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  2. Multimodality Craniofacial Phenotyping of Congenital Facial Weakness Disorders.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Shruti JapeeLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA. Electronic address: japees@mail.nih.gov.
Jessica JordanLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
Judith LichtLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
Savannah LokeyLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
Moebius Syndrome Research Consortium
Gang ChenScientific and Statistical Computing Core, NIMH, NIH, Bethesda, MD, USA.
Joseph SnowOffice of the Clinical Director, NIMH, NIH, Bethesda, MD, USA.
Ethylin Wang JabsDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Bryn D WebbDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA; Department of Pediatrics, Division of Genetics and Metabolism, University of Wisconsin-Madison, Madison, WI, USA.
Elizabeth C EngleDepartments of Neurology and Ophthalmology, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA.
Irini ManoliMedical Genomics and Metabolic Genetics, NHGRI, NIH, Bethesda, MD, USA.
Chris BakerLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
Leslie G UngerleiderLaboratory of Brain and Cognition, NIMH, NIH, Bethesda, MD, USA.
National Institute of Mental Health · USBoston Children's Hospital · USIcahn School of Medicine at Mount Sinai · USNational Human Genome Research Institute · USNational Institutes of Health · USOffice of the Director · USUniversity of Wisconsin–Madison · US

Funding

Functional Anatomy of Face Processing in the Primate BrainZIAMH002918 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI UNGERLEIDER, LESLIE G · 2009 to 2021
$23.2M
Genetic Analysis and Manipulation Core (GAEC)P50HD105351 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI Hisashi Umemori · 2021 to 2026
$9.4M
Genetics of Moebius syndrome and other congenital facial weakness disordersZIAHG200389 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI COLLINS, FRANCIS S. · 2013 to 2024
$4.9M
Birth Defects: Moebius syndrome and related facial weakness disordersU01HD079068 · NICHD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BROOKS, BRIAN PATRICK, ENGLE, ELIZABETH C. · 2014 to 2016
$1.1M
TOPICS IN GENETIC ANALYSIS--ERRORS AND TWO-LOCUS MODELSK01HG000055 · NHGRI · ROCKEFELLER UNIVERSITY · PI GORDON, DEREK · 2000 to 2004
$457k
Intramural NIH HHS ZIA HG200389Intramural NIH HHS ZIA MH002918NHGRI NIH HHS K01 HG000055NICHD NIH HHS P50 HD105351NICHD NIH HHS U01 HD079068
6 · The paper itself

Abstract

Humans rely heavily on facial expressions for social communication to convey their thoughts and emotions and to understand them in others. One prominent but controversial view is that humans learn to recognize the significance of facial expressions by mimicking the expressions of others. This view predicts that an inability to make facial expressions (e.g., facial paralysis) would result in reduced perceptual sensitivity to others' facial expressions. To test this hypothesis, we developed a diverse battery of sensitive emotion recognition tasks to characterize expression perception in individuals with Moebius Syndrome (MBS), a congenital neurological disorder that causes facial palsy. Using computer-based detection tasks we systematically assessed expression perception thresholds for static and dynamic face and body expressions. We found that while MBS individuals were able to perform challenging perceptual control tasks and body expression tasks, they were less efficient at extracting emotion from facial expressions, compared to matched controls. Exploratory analyses of fMRI data from a small group of MBS participants suggested potentially reduced engagement of the amygdala in MBS participants during expression processing relative to matched controls. Collectively, these results suggest a role for facial mimicry and consequent facial feedback and motor experience in the perception of others' facial expressions.

Indexed as

Facial ParalysisFacial RecognitionMobius SyndromeEmotionsFacial ExpressionHumansPerceptionSocial PerceptionEmotion perceptionFacial experienceFacial expressionsFacial feedbackFacial mimicry

Identifiers

PMID37852041
PMCPMC10836030
OpenAlexW4387213877

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.