Evidence map›Paper›PMID 37851816›Full record

ArticleScience advances2023

A self-assembled implantable microtubular pacemaker for wireless cardiac electrotherapy.

Shaolei Wang, Qingyu Cui, Parinaz Abiri, Mehrdad Roustaei, Enbo Zhu, Yan-Ruide Li, Kaidong Wang, Sandra Duarte, Lili Yang, Ramin Ebrahimi and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
18.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 57 citations in OpenAlex.

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  14. Novel Electroactive Therapeutic Platforms for Cardiac Arrhythmia Management.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  15. Advances in 2D materials for wearable biomonitoring.Materials science & engineering. R, Reports : a review journal · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Shaolei WangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8991-0550
Qingyu CuiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Parinaz AbiriDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-0520-6863
Mehrdad RoustaeiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Enbo ZhuDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-8600-8553
Yan-Ruide LiDepartment of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.
Kaidong WangDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5196-9346
Sandra DuarteDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.
Lili YangDepartment of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-6568-0404
Ramin EbrahimiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-3728-1339
Malcolm BersohnDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0009-0006-6706-502X
Jun ChenDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3439-0495
Tzung K HsiaiDepartment of Bioengineering, University of California Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1734-0792
University of California, Los Angeles · US

Funding

UCLA-Caltech Medical Scientist Training ProgramT32GM008042 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AJIJOLA, OLUJIMI A, DAWSON, DAVID WAYNE · 1985 to 2023
$29.9M
The Effect of Nanoparticle Encapsulated Resveratrol on Treatment of PeriodontitisKL2TR001882 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Elizabeta Nemeth · 2016 to 2026
$13.1M
Shear Stress and Light-Sheets to Study Cardiac TrabeculationR01HL129727 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2015 to 2024
$3.5M
Electronica Impedance to Access Metabolically Active PlaqueR01HL118650 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K · 2014 to 2022
$3.3M
Intravascular Deployment of a Wirelessly Powered Micro-PacerR01HL149808 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Tzung K Hsiai · 2020 to 2026
$2.8M
Integrating Volumetric Light-Field with Computational Fluid Dynamics to Study Myocardial Trabeculation and FunctionR01HL159970 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI HSIAI, TZUNG K, MARSDEN, ALISON L · 2021 to 2024
$2.0M
BLRD VA I01 BX004356NCATS NIH HHS KL2 TR001882NHLBI NIH HHS R01 HL118650NHLBI NIH HHS R01 HL129727NHLBI NIH HHS R01 HL149808NHLBI NIH HHS R01 HL159970NIGMS NIH HHS T32 GM008042
6 · The paper itself

Abstract

The current cardiac pacemakers are battery dependent, and the pacing leads are prone to introduce valve damage and infection, plus a complete pacemaker retrieval is needed for battery replacement. Despite the reported wireless bioelectronics to pace the epicardium, open-chest surgery (thoracotomy) is required to implant the device, and the procedure is invasive, requiring prolonged wound healing and health care burden. We hereby demonstrate a fully biocompatible wireless microelectronics with a self-assembled design that can be rolled into a lightweight microtubular pacemaker for intravascular implantation and pacing. The radio frequency was used to transfer energy to the microtubular pacemaker for electrical stimulation. We show that this pacemaker provides effective pacing to restore cardiac contraction from a nonbeating heart and have the capacity to perform overdrive pacing to augment blood circulation in an anesthetized pig model. Thus, this microtubular pacemaker paves the way for the minimally invasive implantation of leadless and battery-free microelectronics.

Indexed as

Cardiac Pacing, ArtificialPacemaker, ArtificialAnimalsElectric StimulationEquipment DesignHeartProstheses and ImplantsSwineTreatment Outcome

Identifiers

PMID37851816
PMCPMC10584332
OpenAlexW4387761047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.