ArticlePloS one2023
Associations between Social Isolation Index and changes in grip strength, gait speed, bone mineral density (BMD), and self-reported incident fractures among older adults: Results from the Canadian Longitudinal Study on Aging (CLSA).
Article in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Social isolation and sarcopenia: the mediating role of physical activity and the intersocietal differences from US and China.Social psychiatry and psychiatric epidemiology · 2026Article
- Short- and Long-Term Effects of Social Isolation on Adult Murine Bone are Sex-Dependent.bioRxiv : the preprint server for biology · 2026Article
- Associations of gait speed, grip strength, depressive symptoms, and their combinations with fracture risk in older adults.GeroScience · 2026Article
- Reducing muscle weakness in nursing home residents: a study quantifying acceptance and feasibility of a formal training algorithm, and reliability of endpoint measures.Aging clinical and experimental research · 2026Article
- Social isolation, loneliness, genetic susceptibility, and the hazard of incident osteoporosis.International journal of surgery (London, England) · 2026Article
- Can Hounsfield Unit Evaluation of Preoperative CT Scans Predict Surgeon's Preference of Cementless Fixation in Total Knee Arthroplasty?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2025Article
- The association of loneliness with bone mineral density, osteoporosis, osteopenia, fall, and sarcopenia among older adults: results from Mr. and Ms. Os (Hong Kong) study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025Article
- Exploring social determinants of health in the context of metabolic and circadian influences on new hip fracture risk: longitudinal insights from CHARLS.BMC public health · 2025Article
- Thermoneutral housing has limited effects on social isolation-induced bone loss in male C57BL/6J mice.JBMR plus · 2025Article
- Social isolation, loneliness and the relationship with serum biomarkers, functional parameters and mortality in older adults.Aging clinical and experimental research · 2025Article
- Progress of systematic psychological interventions in elderly patients with femoral fractures: A comprehensive review.World journal of psychiatry · 2024Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe aim is to investigate whether social isolation and loneliness are associated with changes in grip strength, gait speed, BMD, and fractures.
methodsCanadian Longitudinal Study on Aging (CLSA) Comprehensive Cohort participants aged 65 years and older at baseline (2012-2015) who completed the three-year follow-up interview (2015-2018) were included in this analysis (n = 11,344). Social isolation and loneliness were measured using the CLSA social isolation index (CLSA-SII, range 0-10). We calculated absolute and percent change in grip strength (kg) and gait speed (m/s) and annualized absolute (g/cm2) and percent change in femoral neck and total hip BMD during the three-year follow-up. Self-reported incident fractures of all skeletal sites in the previous 12 months were measured at three-year follow-up. Multivariable analyses were conducted. Odd ratio (OR) and 95% confidence interval (CI) are reported.
resultsThe mean age (standard deviation [SD]) was 72.9 (5.6) years and 49.9% were female. The mean (SD) of CLSA-SII at baseline was 3.5 (1.4). Mean absolute and percentage change (SD) in grip strength (kg) and gait speed (m/s) were -1.33 (4.60), -3.02% (16.65), and -0.05 (0.17), -3.06% (19.28) during the three-year follow-up, respectively. Mean annualized absolute (g/cm2) and percentage change (SD) in femoral neck and total hip BMD were -0.004 (0.010), -0.47% (1.43) and -0.005 (0.009), -0.57% (1.09), respectively. 345 (3.1%) participants had incident fractures. As CLSA-SII increased (per one unit change), participants had 1.13 (adjusted OR 1.13, 95% CI 1.01-1.27) times greater odds for incident fractures. The interaction term between the CLSA-SII and centre for epidemiology studies depression 9 scale (CES-D 9) for self-reported incident fractures was shown (interaction OR 1.02, 95% CI 1.00-1.04).
conclusionsSocially isolated and lonely older adults were more likely to have had incident fractures, but social isolation was not associated with the three-year changes in grip strength, gait speed, or BMD.
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