Evidence map›Paper›PMID 37851400›Full record

ArticleRheumatology (Oxford, England)2024

A decade of progress in juvenile idiopathic arthritis treatments and outcomes in Canada: results from ReACCh-Out and the CAPRI registry.

Kelly Nguyen, Julie Barsalou, Daniah Basodan, Michelle Batthish, Susanne M Benseler, Roberta A Berard, Nicholas Blanchette, Gilles Boire, Roxana Bolaria, Alessandra Bruns and 64 more

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

74 authors at 17 institutions in 2 countries.

Kelly NguyenDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Julie BarsalouDepartment of Pediatrics, Université de Montréal, Montréal, QC, Canada.
Daniah BasodanDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Michelle BatthishDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.ORCID 0000-0001-6412-1029
Susanne M BenselerDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.ORCID 0000-0002-3543-5640
Roberta A BerardDepartment of Pediatrics, Western University, London, ON, Canada.ORCID 0000-0003-2780-0617
Nicholas BlanchetteHealth Sciences North, Sudbury, ON, Canada.
Gilles BoireDepartment of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada.ORCID 0000-0003-2481-5821
Roxana BolariaDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Alessandra BrunsDepartment of Pediatrics, Université de Sherbrooke, Sherbrooke, QC, Canada.
David A CabralDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Bonnie CameronDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Sarah CampilloDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Tania CellucciDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Mercedes ChanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Gaëlle ChédevilleDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Anne-Laure ChetailleDepartment of Pediatrics, CHU de Québec-Université Laval, Québec, Canada.
Amieleena ChhabraDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Julie CoutureDepartment of Pediatrics, Université de Montréal, Montréal, QC, Canada.
Paul DanceyDepartment of Pediatrics, Memorial University, St. John's, NL, Canada.
Jean-Jacques De BruyckerDepartment of Pediatrics, Université de Montréal, Montréal, QC, Canada.
Erkan DemirkayaDepartment of Pediatrics, Western University, London, ON, Canada.
Muhammed DhallaDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Ciarán M DuffyDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Brian M FeldmanDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.ORCID 0000-0002-7813-9665
Debbie E FeldmanDepartment of Pediatrics, Université de Montréal, Montréal, QC, Canada.
Tommy GerschmanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Elie HaddadDepartment of Pediatrics, Université de Montréal, Montréal, QC, Canada.
Liane HealeDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Julie HerringtonDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Kristin HoughtonDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-7174-1007
Adam M HuberDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.ORCID 0000-0002-6616-1689
Andrea HumanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Nicole JohnsonDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Roman JurencakDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Bianca LangDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Maggie LarchéDepartment of Pediatrics, McMaster University, Hamilton, ON, Canada.
Ronald M LaxerDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Claire M LeBlancDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Jennifer J Y LeeDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Deborah M LevyDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Lillian LimDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Lily S H LimDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Nadia LucaDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Tara McGrathDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Tamara McMillanDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Paivi M MiettunenDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Kimberly A MorishitaDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Hon Yan NgDepartment of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.
Kiem OenDepartment of Pediatrics, University of Manitoba, Winnipeg, MB, Canada.
Jonathan ParkDepartment of Pediatrics, Western University, London, ON, Canada.ORCID 0000-0001-6093-5500
Ross E PettyDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Jean-Philippe Proulx-GauthierDepartment of Pediatrics, CHU de Québec-Université Laval, Québec, Canada.
Suzanne RamseyDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Johannes RothDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Alan M RosenbergDepartment of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.ORCID 0000-0002-0109-1595
Evelyn RozenblyumDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Dax G RumseyDepartment of Pediatrics, University of Alberta, Edmonton, AB, Canada.
Heinrike SchmelingDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Rayfel SchneiderDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Rosie ScuccimarriDepartment of Pediatrics, McGill University, Montreal, QC, Canada.
Natalie J ShiffDepartment of Pediatrics, University of Saskatchewan, Saskatoon, SK, Canada.ORCID 0000-0002-7410-9709
Earl SilvermanDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Gordon SoonHealth Sciences North, Sudbury, ON, Canada.
Lynn SpiegelDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Elizabeth StringerDepartment of Pediatrics, Dalhousie University, Halifax, NS, Canada.
Herman TamDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Shirley M TseDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Lori B TuckerDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Stuart TurveyDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.
Marinka TwiltDepartment of Pediatrics, University of Calgary, Calgary, AB, Canada.
Karen Watanabe DuffyDepartment of Pediatrics, University of Ottawa, Ottawa, ON, Canada.
Rae S M YeungDepartment of Pediatrics, University of Toronto, Toronto, ON, Canada.
Jaime GuzmanDepartment of Pediatrics, University of British Columbia, Vancouver, BC, Canada.ORCID 0000-0001-8977-2581
University of British Columbia · CAUniversity of Toronto · CAUniversity of Calgary · CAMcMaster University · CAUniversité de Montréal · CAUniversity of Alberta · CAUniversity of Ottawa · CADalhousie University · CAMcGill University Health Centre · CAUniversity of Saskatchewan · CAWestern University · CACentre hospitalier de l'Université Laval · CAUniversité de Sherbrooke · CAUniversity of Manitoba · CAHealth Sciences North · CAMemorial University of Newfoundland · CANorth York General Hospital · CA

Funding

BC Children's Hospital Research InstituteCIHR PJT-175235CIHR QNT 69301Fast FoundationNew Emerging TeamThe Arthritis Society Canada CAPRI-15-001 SOG 18-0352
6 · The paper itself

Abstract

objectiveTo assess changes in juvenile idiopathic arthritis (JIA) treatments and outcomes in Canada, comparing 2005-2010 and 2017-2021 inception cohorts.

methodsPatients enrolled within three months of diagnosis in the Research in Arthritis in Canadian Children Emphasizing Outcomes (ReACCh-Out) and the Canadian Alliance of Pediatric Rheumatology Investigators Registry (CAPRI) cohorts were included. Cumulative incidences of drug starts and outcome attainment within 70 weeks of diagnosis were compared with Kaplan-Meier survival analysis and multivariable Cox regression.

resultsThe 2005-2010 and 2017-2021 cohorts included 1128 and 721 patients, respectively. JIA category distribution and baseline clinical juvenile idiopathic arthritis disease activity (cJADAS10) scores at enrolment were comparable. By 70 weeks, 6% of patients (95% CI 5, 7) in the 2005-2010 and 26% (23, 30) in the 2017-2021 cohort had started a biologic DMARD (bDMARD), and 43% (40, 47) and 60% (56, 64) had started a conventional DMARD (cDMARD), respectively. Outcome attainment was 64% (61, 67) and 83% (80, 86) for inactive disease (Wallace criteria), 69% (66, 72) and 84% (81, 87) for minimally active disease (cJADAS10 criteria), 57% (54, 61) and 63% (59, 68) for pain control (<1/10), and 52% (47, 56) and 54% (48, 60) for good health-related quality of life (≥9/10).

conclusionAlthough baseline disease characteristics were comparable in the 2005-2010 and 2017-2021 cohorts, cDMARD and bDMARD use increased with a concurrent increase in minimally active and inactive disease. Improvements in parent and patient-reported outcomes were smaller than improvements in disease activity.

Indexed as

Antirheumatic AgentsArthritis, JuvenileRegistriesAdolescentBiological ProductsCanadaChildChild, PreschoolFemaleHumansMaleSeverity of Illness IndexTreatment OutcomeAntirheumatic AgentsBiological Productsjuvenile arthritisoutcomesprognosistreatment

Identifiers

PMID37851400
PMCPMC11381684
OpenAlexW4387728585

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.