ArticleAnnals of intensive care2023
Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study.
Article in Annals of intensive care, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04711759 (Postextubation High-flow Nasal Cannula Versus Standard Oxygen Therapy in Critically Ill Patients), which is not on this map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Postextubation High-flow Nasal Cannula Versus Standard Oxygen Therapy in Critically Ill Patients: a Physiologic Randomized Crossover Study
Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Feasibility and safety of oxygen-free nasal high flow therapy in the acute postoperative period: a single-center randomized study.BMC anesthesiology · 2026Trial
- Physiological Effects of High-Flow Nasal Oxygen Compared With Conventional Oxygen Therapy: A Randomized Trial in Postextubation Patients.Critical care medicine · 2026Trial
- Trial
- Physiological comparison of noninvasive ventilation and high-flow nasal oxygen on inspiratory efforts and tidal volumes after extubation: a randomized crossover trial.Critical care (London, England) · 2025Trial
- High-flow nasal cannula oxygen during breaks from noninvasive ventilation after extubation: an observational study.Intensive care medicine · 2026Observational
- Physiological comparison of noninvasive ventilation and CPAP on inspiratory efforts after extubation in critically ill patients with morbid obesity: a post-hoc analysis.Annals of intensive care · 2025Article
- Bridging the Gap: The Role of Non-Invasive Respiratory Supports in Weaning from Invasive Mechanical Ventilation.Journal of clinical medicine · 2025Review
- Electrical impedance tomography: from technical innovations to bedside clinical solutions.World journal of emergency medicine · 2025Article
- Impact of pressure support ventilation duration after a spontaneous breathing trial on reintubation rates in critically ill subjects: a retrospective study.BMC pulmonary medicine · 2025Article
- High-Flow Nasal Cannula Application After Extubation in Acute Respiratory Failure Patients.Journal of clinical medicine · 2025Article
- High-flow nasal cannula oxygen therapy: physiological basis and clinical applications in anesthesia.Frontiers in medicine · 2025Review
- Article
- Letter on "Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study".Annals of intensive care · 2024Article
- Reply letter on "Physiological effects of high-flow nasal cannula oxygen therapy after extubation: a randomized crossover study".Annals of intensive care · 2024Article
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Authors and funding
14 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundProphylactic high-flow nasal cannula (HFNC) oxygen therapy can decrease the risk of extubation failure. It is frequently used in the postextubation phase alone or in combination with noninvasive ventilation. However, its physiological effects in this setting have not been thoroughly investigated. The aim of this study was to determine comprehensively the effects of HFNC applied after extubation on respiratory effort, diaphragm activity, gas exchange, ventilation distribution, and cardiovascular biomarkers.
methodsThis was a prospective randomized crossover physiological study in critically ill patients comparing 1 h of HFNC versus 1 h of standard oxygen after extubation. The main inclusion criteria were mechanical ventilation for at least 48 h due to acute respiratory failure, and extubation after a successful spontaneous breathing trial (SBT). We measured respiratory effort through esophageal/transdiaphragmatic pressures, and diaphragm electrical activity (ΔEAdi). Lung volumes and ventilation distribution were estimated by electrical impedance tomography. Arterial and central venous blood gases were analyzed, as well as cardiac stress biomarkers.
resultsWe enrolled 22 patients (age 59 ± 17 years; 9 women) who had been intubated for 8 ± 6 days before extubation. Respiratory effort was significantly lower with HFNC than with standard oxygen therapy, as evidenced by esophageal pressure swings (5.3 [4.2-7.1] vs. 7.2 [5.6-10.3] cmH
conclusionsProphylactic application of HFNC after extubation provides substantial respiratory support and unloads respiratory muscles. Trial registration January 15, 2021. NCT04711759.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.