ArticleThe journal of spinal cord medicine2025
Age-dependent effect of vitamin D supplementation on musculoskeletal health in chronic spinal cord injury patients: A pilot study.
Article in The journal of spinal cord medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo determine the effect of vitamin D supplementation on changes in body composition associated with musculoskeletal health status in patients with chronic SCI and vitamin D deficiency as a response to age.
designProspective drug-intervention study.
settingDepartment of rehabilitation medicine, Veterans Health Service Medical Center.
participantsSeventeen patients with vitamin D insufficiency/deficiency (<30 ng/mL) and chronic SCI were divided into two groups: groups A <65 years (
interventionsBoth groups received 800 IU/day cholecalciferol for 12 weeks. OUTCOME MEASURES: We used blood samples to evaluate metabolites related to vitamin D, testosterone (T), lipid profiles, and sex hormone-binding globulin (SHBG). Bioelectrical impedance analysis (BIA) was used to evaluate body composition.
resultsGroup A had significantly better baseline clinical characteristics for all BIA measurements. SHGB was significantly higher in Group B (
conclusionThis study suggested that addressing vitamin D deficiency in patients with SCI had different effects in young and older adults, with both groups showing positive changes in body composition. Particularly, the increase in PM on BIA measurements in elderly patients at high risk of sarcopenia was encouraging.
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