Evidence map›Paper›PMID 37850798›Full record

ArticleJournal of bacteriology2024

Nonadditive functional interactions between ligand-binding sites of the multidrug efflux pump AdeB from

Inga V Leus, Sean R Roberts, Anhthu Trinh, Edward W Yu, Helen I Zgurskaya

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bacteriology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Inga V LeusDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0001-8906-717X
Sean R RobertsDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.
Anhthu TrinhDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.
Edward W YuDepartment of Pharmacology, Case Western Reserve University School of Medicine , Cleveland, Ohio, USA.
Helen I ZgurskayaDepartment of Chemistry and Biochemistry, University of Oklahoma , Norman, Oklahoma, USA.ORCID 0000-0001-8929-4727
University of Oklahoma · USUniversity School · US

Funding

Transport across two membranes by AcrAB-TolC complexR01AI052293 · NIAID · UNIVERSITY OF OKLAHOMA NORMAN · PI ZGURSKAYA, HELEN I · 2003 to 2024
$7.7M
Emerging antibiotic resistance in Gram-negative pathogensR01AI145069 · NIAID · CASE WESTERN RESERVE UNIVERSITY · PI YU, EDWARD W · 2019 to 2023
$3.3M
NIAID NIH HHS R01 AI052293NIAID NIH HHS R01 AI145069
6 · The paper itself

Abstract

Multidrug efflux is one of the major mechanisms of antibiotic resistance identified in clinical isolates of the human pathogen

Indexed as

Acinetobacter baumanniiEscherichia coli ProteinsAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsBinding SitesDrug Resistance, Multiple, BacterialEscherichia coliHumansLigandsMembrane Transport ProteinsMicrobial Sensitivity TestsAcrB protein, E coliAnti-Bacterial AgentsATP-Binding Cassette, Sub-Family C ProteinsBacterial ProteinsEscherichia coli ProteinsLigandsMembrane Transport ProteinsAcinetobacter baumanniiantibiotic resistancemultidrug efflux

Identifiers

PMID37850798
PMCPMC10809976
OpenAlexW4387729001

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.