Evidence map›Paper›PMID 37850777›Full record

ArticleActa bio-medica : Atenei Parmensis2023

Combination treatment of dupilumab with bortezomib in a patient with IgG kappa gammopathy of renal significance, uremic pruritus and chronic lichenoid dermatitis.

Paolino Giovanni, Matteo Riccardo Di Nicola, Magda Marcatti, Nathalie Rizzo, Vittoria Bianchi, Valeria Ferla, Santo Raffaele Mercuri

Open access · greenAbstract readCase Reports
In one paragraph

Article in Acta bio-medica : Atenei Parmensis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paolino GiovanniIRCCS San Raffaele Hospital. paolino.giovanni@hsr.it.
Matteo Riccardo Di NicolaIRCCS San Raffaele Hospital. dinicola.matteo@hsr.it.
Magda MarcattiIRCCS San Raffaele Hospital. marcatti.magda@hsr.it.
Nathalie RizzoIRCCS San Raffaele Hospital. Rizzo.Nathalie@hsr.it.
Vittoria BianchiIRCCS San Raffaele Hospital. bianchi.vittoriagiulia@hsr.it.
Valeria FerlaIRCCS San Raffaele Hospital. Ferla.Valeria@hsr.it.
Santo Raffaele MercuriIRCCS San Raffaele Hospital. Mercuri.SantoRaffaele@hsr.it.
Vita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic pruritus (CP) is one of the most frequent symptoms among dermatological conditions, capable of reducing the quality of life (QoL). CP may be induced by atopic dermatitis or other dermatological and/or non-dermatological conditions. In this article, we report the case of a patient affected by generalized CP, characterised by multiple papulo-nodular and escoriatic lesions, developed after the onset of an immunoglobulin G (IgG) kappa monoclonal gammopathy of renal significance (MGRS), associated with renal insufficiency. Therefore, a combined treatment with dupilumab for CP and bortezomib for the hematologic malignancy was administered to the patient. The present case report highlights the efficacy of dupilumab for the treatment of CP. Moreover, no relevant side effects were recorded during the treatment in combination with other systemic biological drugs for other systemic pathologies.

Indexed as

Dermatitis, AtopicQuality of LifeAntibodies, Monoclonal, HumanizedBortezomibHumansImmunoglobulin GPruritusSeverity of Illness IndexTreatment OutcomeAntibodies, Monoclonal, HumanizedBortezomibdupilumabImmunoglobulin G

Identifiers

PMID37850777
PMCPMC10644923
OpenAlexW4387729118

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.