ArticleFrontiers in endocrinology2023
The association between thyroid-stimulating hormone and thyroid nodules, goiter and thyroid antibody positivity.
Article in Frontiers in endocrinology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 5 citations in OpenAlex.
- Ultrasound-Guided Microwave Ablation for Benign Thyroid Nodules in Older Adults: Comparative Analysis of Clinical Outcomes and Safety.Diagnostics (Basel, Switzerland) · 2026Article
- Thyroid hormones are associated with pituitary and thyroid volume in a population-based study.Journal of the Endocrine Society · 2026Article
- Reactive oxygen species and intrinsic apoptotic markers in thyroid dysfunction: Insights from experimental animal models.Open veterinary journal · 2026Article
- Occurrence of clinically relevant thyroid nodules in adults.Radiology and oncology · 2026Article
- Retrospective analysis of thyroid functions and sonographic characteristics of the thyroid gland in a health check-up population in China during 2020-2024.Frontiers in public health · 2026Article
- Hashimoto's thyroiditis in an Egyptian cohort: clinical, functional, and ultrasonographic features with insights into nodule risk.Frontiers in endocrinology · 2025Article
- An investigation of the pattern and mechanism of comorbidity in patients with Hashimoto's thyroiditis.Frontiers in endocrinology · 2025Article
- A study on the correlation of thyroid nodules with METS-IR and SII in a population undergoing health checkups.Frontiers in endocrinology · 2025Article
- Sex-specific associations between the developmental alterations in the pituitary-thyroid hormone axis and thyroid nodules in Chinese euthyroid adults: a community-based cross-sectional study.Frontiers in endocrinology · 2024Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The relationship between normal thyroid-stimulating hormone (TSH) levels and thyroid disease in adults remains controversial. This study aimed to investigate the correlation between serum TSH levels, particularly those falling within the normal range, and thyroid diseases in Chinese adults, including thyroid nodules (TN), goiter (GR), and thyroid antibody positivity. Materials and methods: This research was a cross-sectional study conducted in an adult population in Tianjin, China. Thyroid volume (Tvol) and TN were assessed using thyroid ultrasonography. Fasting venous blood and spot urine samples were collected to evaluate thyroid function and iodine status. Results: A total of 2460 subjects participated in the survey. The prevalence of thyroid dysfunction was 9.76%, and abnormal TSH levels were found to potentially increase the risk of GR and thyroid antibody positivity in adults. A total of 2220 subjects with TSH within the normal reference range were included in the further study. In these patients, Tvol decreased as TSH levels increased, in both men and women ( Conclusion: In adults with normal TSH levels, low TSH levels were associated with an increased risk of TN and GR, whereas high TSH levels were associated with thyroid antibody positivity. The research also suggests that adults whose TSH levels at upper or lower limits of the normal range should be reviewed regularly.
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