ArticleACS medicinal chemistry letters2023
Expanding the Chemical Space: New Approach to Cell-Permeable Drugs.
Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This Patent Highlight explores the development of cell-permeable drugs, moving beyond traditional low molecular weight, nonpolar, and rigid compounds. It introduces a novel compound combining two types of Abelson murine leukemia (ABL) enzyme inhibitors. This compound offers potential therapeutic applications, including cancer, neurodegenerative diseases, and ABL-associated disease treatment. Moreover, it can reduce ABL activity levels in cells. These advancements illustrate the potential of "beyond the rule of five" compounds in drug discovery and clinical applications, expanding the chemical space for future research and development.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.