Evidence map›Paper›PMID 37849402›Full record

ReviewThe Journal of infectious diseases2023

A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures.

Richard J Kuhn, Alan D T Barrett, Aravinda M Desilva, Eva Harris, Laura D Kramer, Ruth R Montgomery, Theodore C Pierson, Alessandro Sette, Michael S Diamond

Abstract readReview
In one paragraph

Review in The Journal of infectious diseases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Viral Prototypes for Pandemic Preparedness: The Road Ahead.The Journal of infectious diseases · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Richard J KuhnDepartment of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.ORCID 0000-0003-4148-1026
Alan D T BarrettDepartment of Pathology, University of Texas Medical Branch, Galveston, Texas, USA.
Aravinda M DesilvaDepartment of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Eva HarrisDivision of Infectious Diseases and Vaccinology, School of Public Health, University of California Berkeley, Berkeley, California, USA.
Laura D KramerSchool of Public Health, State University of New York at Albany, Albany, New York, USA.
Ruth R MontgomeryDepartment of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Theodore C PiersonResearch Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Alessandro SetteDivision of Vaccine Discovery, La Jolla Institute for Immunology, La Jolla, California, USA.
Michael S DiamondDepartment of Medicine, Washington University School of Medicine, St Louis, Missouri, USA.

Funding

Antibody-based Protection against FlavivirsesR01AI073755 · NIAID · WASHINGTON UNIVERSITY · PI DIAMOND, MICHAEL S, FREMONT, DAVED H. · 2007 to 2022
$11.4M
NIAID NIH HHS R01 AI073755
6 · The paper itself

Abstract

Flaviviruses are a genus within the Flaviviridae family of positive-strand RNA viruses and are transmitted principally through mosquito and tick vectors. These viruses are responsible for hundreds of millions of human infections worldwide per year that result in a range of illnesses from self-limiting febrile syndromes to severe neurotropic and viscerotropic diseases and, in some cases, death. A vaccine against the prototype flavivirus, yellow fever virus, has been deployed for 85 years and is highly effective. While vaccines against some medically important flaviviruses are available, others have proven challenging to develop. The emergence and spread of flaviviruses, including dengue virus and Zika virus, demonstrate their pandemic potential. This review highlights the gaps in knowledge that need to be addressed to allow for the rapid development of vaccines against emerging flaviviruses in the future.

Indexed as

FlavivirusFlavivirus InfectionsVaccinesZika VirusZika Virus InfectionAnimalsHumansMosquito VectorsVaccinesantibody-dependent enhancementantibody neutralizationarbovirusdynamicsflavivirusinterferonvaccinevirus-host interaction

Identifiers

PMID37849402
PMCPMC10582523

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.