Evidence map›Paper›PMID 37849233›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2023

Deciphering the Functional Long Non-Coding RNAs Derived from MicroRNA Loci.

Weiqian Li, Yue Huo, Yue Ren, Chenxi Han, Shuo Li, Kangning Wang, Manman He, Yiying Chen, Yanran Wang, Lingjie Xu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Deciphering the Functional Long Non-Coding RNAs Derived from MicroRNA Loci.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Weiqian LiState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yue HuoState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yue RenState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Chenxi HanState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Shuo LiState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Kangning WangState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Manman HeState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yiying ChenState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yanran WangState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Lingjie XuEmergency Department of West China Hospital, Sichuan University, Chengdu, 610041, P.R. China.
Yuehong GuoState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yanmin SiState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yufeng GaoState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Jiayue XuState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Xiaoshuang WangState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Yanni MaState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.
Jia YuState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.ORCID 0000-0003-3499-5133
Fang WangState Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Haihe Laboratory of Cell Ecosystem, The Key Laboratory of RNA and Hematopoietic Regulation, Chinese Academy of Medical Sciences / Peking Union Medical College, Beijing, 100005, P.R. China.

Funding

CAMS Innovation Fund for Medical Sciences 2021-I2M-1-019CAMS Innovation Fund for Medical Sciences 2021-I2M-1-040Fundamental Research Funds for the Core Facility 3332019001National Key Research and Development Program of China 2019YFA0801800National Key Research and Development Program of China 2021YFA1102400National Natural Science Foundation of China 31725013National Natural Science Foundation of China 81530007National Natural Science Foundation of China 81970103National Natural Science Foundation of China 82022001National Natural Science Foundation of China 82100135National Natural Science Foundation of China 82300140
6 · The paper itself

Abstract

Albeit the majority of eukaryotic genomes can be pervasively transcribed to a diverse population of lncRNAs and various subtypes of lncRNA are discovered. However, the genome-wide study of miRNA-derived lncRNAs is still lacking. Here, it is reported that over 800 miRNA gene-originated lncRNAs (molncRNAs) are generated from miRNA loci. One of them, molnc-301b from miR-301b and miR-130b, functions as an "RNA decoy" to facilitate dissociation of the chromatin remodeling protein SMARCA5 from chromatin and thereby sequester transcription and mRNA translation. Specifically, molnc-301b attenuates erythropoiesis by mitigating the transcription of erythropoietic and translation-associated genes, such as GATA1 and FOS. In addition, a useful and powerful CRISPR screen platform to characterize the biological functions of molncRNAs at large-scale and single-cell levels is established and 29 functional molncRNAs in hematopoietic cells are identified. Collectively, the focus is on miRNA-derived lncRNAs, deciphering their landscape during normal hematopoiesis, and comprehensively evaluating their potential roles.

Indexed as

MicroRNAsRNA, Long NoncodingGenome-Wide Association StudyTranscription FactorsMicroRNAsRNA, Long NoncodingTranscription FactorsCRISPR screenmiR-301bmiRNA gene-originated lncRNAs (molncRNAs)SMARCA5

Identifiers

PMID37849233
PMCPMC10667839

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.