Evidence map›Paper›PMID 37848996›Full record

ArticleAdvances in rheumatology (London, England)2023

The effect of PD-1/PD-L1 signaling axis on the interaction between CD19

Zhuobei Xie, Li Dai, Haohua He, Dengxiao Hong, Honghui Tang, Wenyan Xu, Zhongxin Chen, Hongtao Wang, Baiqing Li, Changhao Xie and 1 more

Open access · diamondAbstract read
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In one paragraph

Article in Advances in rheumatology (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Zhuobei XieDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.ORCID 0009-0008-5240-6893
Li DaiDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.
Haohua HeDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.
Dengxiao HongDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.
Honghui TangClinical Medical College of Bengbu Medical College, Bengbu, 233003, China.
Wenyan XuDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.
Zhongxin ChenDepartment of Clinical Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China.
Hongtao WangAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu, 233003, China.
Baiqing LiAnhui Provincial Key Laboratory of Immunology in Chronic Diseases, Bengbu Medical College, Bengbu, 233003, China.
Changhao XieDepartment of Rheumatology and Immunology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, 233003, China. uglboy2021@126.com.ORCID 0000-0001-5039-5969
Yuanyuan WangDepartment of Histology and Embryology, Bengbu Medical College, Bengbu, 233003, China. wangyuanyuantcm@126.com.
Bengbu Medical College · CN

Funding

Anhui Bengbu Medical College Postgraduate Research Innovation Project Byycx21064Anhui Bengbu Medical College Postgraduate Research Innovation Project Byycx22028Anhui Bengbu Medical College Postgraduate Research Innovation Project Byycxz21093Anhui Provincial Natural Science Fund Surface Project 2108085MH258Key Project of the Natural Science Foundation Universities Anhui Province KJ2021A0763the national college students' Innovation and Entrepreneurship training Program 202210367066
6 · The paper itself

Abstract

backgroundThe defect of B cell self-tolerance and the continuous antigen presentation by T cells (TCs) mediated by autoreactive B cells (BCs) play a key role in the occurrence and development of systemic lupus erythematosus (SLE). PD-1/PD-L1 signaling axis negatively regulates the immune response of TCs after activation and maintains immune tolerance. However, the effect of PD-1/PD-L1 signaling axis on the interaction between CD19

methodsPD-1/PD-L1 and Ki-67 levels in peripheral blood (PB) of 50 SLE patients and 41 healthy controls (HCs) were detected through flow cytometry, and then the expression of PD-1

resultsThe PD-1, PD-L1, and Ki-67 levels on CD19

conclusionsAxis of PD-1/PD-L1 on CD19

Indexed as

Interleukin-10Lupus Erythematosus, SystemicB7-H1 AntigenCD4-Positive T-LymphocytesHumansKi-67 AntigenProgrammed Cell Death 1 ReceptorB7-H1 AntigenCD274 protein, humanInterleukin-10Ki-67 AntigenPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCD19+B cellsCD4+T cellsKi-67PD-1/PD-L1 signal axisSLE

Identifiers

PMID37848996
OpenAlexW4387705780

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.