Evidence map›Paper›PMID 37848538›Full record

ArticleCommunications biology2023

The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests.

Ruth Appeltant, Robert Hermes, Susanne Holtze, Silvia Clotilde Modina, Cesare Galli, Briet D Bjarkadottir, Babatomisin V Adeniran, Xi Wei, Aleona Swegen, Thomas Bernd Hildebrandt and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Biobanking biodiversity: recent strategies, challenges, and opportunities.The Journal of reproduction and development · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 5 countries.

Ruth AppeltantNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK.ORCID http://orcid.org/0000-0002-0170-1963
Robert HermesLeibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Str 17, D-10315, Berlin, Germany.ORCID http://orcid.org/0000-0003-2487-9171
Susanne HoltzeLeibniz Institute for Zoo and Wildlife Research, Alfred-Kowalke-Str 17, D-10315, Berlin, Germany.ORCID http://orcid.org/0000-0002-4654-1916
Silvia Clotilde ModinaDipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via dell'Università 6, 26900, Lodi, Italy.
Cesare GalliAvantea srl, Laboratory of Reproductive Technologies, Via Porcellasco 7/F, 26100, Cremona, Italy.ORCID http://orcid.org/0000-0002-9529-6136
Briet D BjarkadottirNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK.
Babatomisin V AdeniranNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK.
Xi WeiNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK.
Aleona SwegenNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK.
Thomas Bernd HildebrandtDipartimento di Medicina Veterinaria, Università degli Studi di Milano, Via dell'Università 6, 26900, Lodi, Italy.
Suzannah A WilliamsNuffield Department of Women's and Reproductive Health, University of Oxford, Women's Centre, Level 3, John Radcliffe Hospital, Oxford, UK. suzannah.williams@wrh.ox.ac.uk.ORCID http://orcid.org/0000-0003-1798-976X
John Radcliffe Hospital · GBLeibniz Institute for Zoo and Wildlife Research · DEUniversity of Milan · ITAvantea · ITUniversity of Antwerp · BE

Funding

Medical Research Council MR/N013468/1
6 · The paper itself

Abstract

The northern white rhinoceros is functionally extinct with only two females left. Establishing methods to culture ovarian tissues, follicles, and oocytes to generate eggs will support conservation efforts using in vitro embryo production. To the best of our knowledge, this is the first description of the structure and molecular signature of any rhinoceros, more specifically, we describe the neonatal and adult southern white rhinoceros (Ceratotherium simum simum) ovary; the closest relation of the northern white rhinoceros. Interestingly, all ovaries contain follicles despite advanced age. Analysis of the neonate reveals a population of cells molecularly characterised as mitotically active, pluripotent with germ cell properties. These results indicate that unusually, the neonatal ovary still contains oogonia in germ cell nests at birth, providing an opportunity for fertility preservation. Therefore, utilising ovaries from stillborn and adult rhinoceros can provide cells for advanced assisted reproductive technologies and investigating the neonatal ovaries of other endangered species is crucial for conservation.

Indexed as

OogoniaOvaryAnimalsEndangered SpeciesFemaleOocytesPerissodactyla

Identifiers

PMID37848538
PMCPMC10582104
OpenAlexW4387696240

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.