ArticleNeurology2023
Altered Sleep Microarchitecture and Cognitive Impairment in Patients With Temporal Lobe Epilepsy.
Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23 citing papers in PubMed, 24 citations in OpenAlex.
- Sleep spindle deficits in childhood absence epilepsy improve with antiseizure treatment and disease resolution.bioRxiv : the preprint server for biology · 2026Article
- Multi-Omics Dissection of the Shared Genetic Architecture Between Sleep Traits and Epilepsy.Biology · 2026Article
- Predictors of cognitive impairment in drug-resistant epilepsy: the role of interictal EEG abnormalities.Acta epileptologica · 2026Article
- Long-term forgetting, sleep, and tau in autosomal-dominant Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Late-onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi-center prospective longitudinal observational study (ELUCID).Epilepsia open · 2026Observational
- Association of Sleep Spindle Activity With Cognitive Decline in Early Clinical Stages of Alzheimer Disease.Neurology · 2026Article
- Sleep and circadian rhythm disruptions in animal models of temporal lobe epilepsy.Frontiers in neuroscience · 2026Review
- Thalamic transcranial electrical stimulation with temporal interference enhances sleep spindle activity during a daytime nap.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Phase precession of spindle-slow oscillation coupling across the human brain.bioRxiv : the preprint server for biology · 2025Article
- Prediction of late seizures after ischemic stroke using cognitive scores.BMC neurology · 2025Article
- Analysis of brain volume in hippocampal sclerotic temporal lobe epilepsy using automatic brain segmentation technology.Quantitative imaging in medicine and surgery · 2025Article
- Interictal network dysfunction and cognitive impairment in epilepsy.Nature reviews. Neuroscience · 2025Review
- Article
- Cognitive Decline in Nasopharyngeal Carcinoma Survivors with Post-Radiation Epilepsy: A Prospective Cohort Study.Cancers · 2025Article
- Mechanistic insights into the interaction between epilepsy and sleep.Nature reviews. Neurology · 2025Review
- Comparison of offspring outcomes in women with and without epilepsy.Annals of clinical and translational neurology · 2025Article
- Clinical characteristics, etiology, and treatment of young adult-onset epilepsy: A 24-year retrospective study.Epilepsia open · 2025Article
- Association of Sleep Spindle Rate With Memory Consolidation in Children With Rolandic Epilepsy.Neurology · 2025Article
- Dreams interrupted: characteristics of REM sleep-associated seizures and status epilepticus.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025Article
- Impaired sleep-dependent memory consolidation predicted by reduced sleep spindles in Rolandic epilepsy.bioRxiv : the preprint server for biology · 2024Article
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7 authors at 1 institution in 1 country.
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Abstract
BACKGROUND AND
objectivesTo investigate the spatiotemporal characteristics of sleep waveforms in temporal lobe epilepsy (TLE) and examine their association with cognition.
methodsIn this retrospective, cross-sectional study, we examined overnight EEG data from adult patients with TLE and nonepilepsy comparisons (NECs) admitted to the epilepsy monitoring unit at Mass General Brigham hospitals. Automated algorithms were used to characterize sleep macroarchitecture (sleep stages) and microarchitecture (spindles, slow oscillations [SOs]) on scalp EEG and to detect hippocampal interictal epileptiform discharges (hIEDs) from foramen ovale electrodes simultaneously recorded in a subset of patients with TLE. We examined the association of sleep features and hIEDs with memory and executive function from clinical neuropsychological evaluations.
resultsA total of 81 adult patients with TLE and 28 NEC adult patients were included with similar mean ages. There were no significant differences in sleep macroarchitecture between groups, including relative time spent in each sleep stage, sleep efficiency, and sleep fragmentation. By contrast, the spatiotemporal characteristics of sleep microarchitecture were altered in TLE compared with NEC and were associated with cognitive impairments. Specifically, we observed a ∼30% reduction in spindle density in patients with TLE compared with NEC, which was significantly associated with worse memory performance. Spindle-SO coupling strength was also reduced in TLE and, in contrast to spindles, was associated with diminished executive function. We found no significant association between sleep macroarchitectural and microarchitectural parameters and hIEDs. DISCUSSION: There is a fundamental alteration of sleep microarchitecture in TLE, characterized by a reduction in spindle density and spindle-SO coupling, and these changes may contribute to neurocognitive comorbidity in this disorder.
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