ArticleProceedings of the National Academy of Sciences of the United States of America2023
Increased homozygosity due to endogamy results in fitness consequences in a human population.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Runs of Homozygosity Predict Inbreeding Depression Across Taxa: A Systematic Review and Meta-Analysis.Molecular ecology · 2026Pooled it
- Recovering the precolonial population structure of Khoe-San descendant populations.Science advances · 2026Article
- From Nuisance to Signal: Leveraging Close Relatives in Biobank-Scale Demographic Inference.bioRxiv : the preprint server for biology · 2026Article
- Genome-Wide Homozygosity Predicts Inbreeding Depression in the Hihi/Stitchbird (Evolutionary applications · 2026Article
- Runs of homozygosity reveal candidate genes for economic traits in Danish Large White pigs.Archives animal breeding · 2026Article
- The Influence of Demographic History and Genetic Architecture on Complex Traits via Runs of Homozygosity.bioRxiv : the preprint server for biology · 2025Article
- No evidence for disassortative mating based on HLA in a small-scale, endogamous population.bioRxiv : the preprint server for biology · 2025Article
- Recovering the pre-colonial population structure of Khoe-San descendant populations.bioRxiv : the preprint server for biology · 2025Article
- Long runs of homozygosity are reliable genomic markers of inbreeding depression.Trends in ecology & evolution · 2025Review
- Article
- Genomic Consequences of Isolation and Inbreeding in an Island Dingo Population.Genome biology and evolution · 2024Article
- The Maintenance of Deleterious Variation in Wild Chinese Rhesus Macaques.Genome biology and evolution · 2024Article
- Detecting inbreeding depression in structured populations.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The influence of gene flow on population viability in an isolated urban caracal population.Molecular ecology · 2024Article
- The Maintenance of Deleterious Variation in Wild Chinese Rhesus Macaques.bioRxiv : the preprint server for biology · 2024Article
- Genomic consequences of isolation and inbreeding in an island dingo population.bioRxiv : the preprint server for biology · 2024Article
- Fine-scale genetic structure and rare variant frequencies.PloS one · 2024Article
- Cross-cousin marriage among Tsimane forager-horticulturalists during demographic transition and market integration.Evolutionary human sciences · 2024Article
- Genomic Underpinnings of Population Persistence in Isle Royale Moose.Molecular biology and evolution · 2023Article
- Examination of runs of homozygosity in relation to height in an endogamous Namibian population.American journal of biological anthropology · 2023Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
Recessive alleles have been shown to directly affect both human Mendelian disease phenotypes and complex traits. Pedigree studies also suggest that consanguinity results in increased childhood mortality and adverse health phenotypes, presumably through penetrance of recessive mutations. Here, we test whether the accumulation of homozygous, recessive alleles decreases reproductive success in a human population. We address this question among the Namibian Himba, an endogamous agro-pastoralist population, who until very recently practiced natural fertility. Using a sample of 681 individuals, we show that Himba exhibit elevated levels of "inbreeding," calculated as the fraction of the genome in runs of homozygosity (F
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