Evidence map›Paper›PMID 37847579›Full record

ArticleJournal of biomaterials science. Polymer edition2024

Type I collagen concentration affects neurite outgrowth of adult rat DRG explants by altering mechanical properties of hydrogels.

Uyen N Nguyen, Fei San Lee, Sydney M Caparaso, Jack T Leoni, Adan L Redwine, Rebecca A Wachs

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomaterials science. Polymer edition, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Uyen N NguyenDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.
Fei San LeeDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.
Sydney M CaparasoDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.
Jack T LeoniDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.
Adan L RedwineDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.
Rebecca A WachsDepartment of Biological Systems Engineering, University of NE-Lincoln, Lincoln, NE, USA.ORCID 0000-0001-5735-6284
University of Nebraska–Lincoln · US

Funding

Targeted mass spectrometry approaches to understand CART processing and recepter interactionsP20GM113126 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI RAZAVI RIZI, MOHAMMAD · 2016 to 2025
$20.8M
Decoupling Mechanical and Inflammatory Stimuli in Discogenic Low Back PainR01AR080926 · NIAMS · UNIVERSITY OF NEBRASKA LINCOLN · PI Rebecca Ann Wachs · 2022 to 2026
$1.5M
Molecular Mechanisms of DiseaseT32GM107001 · NIGMS · UNIVERSITY OF NEBRASKA LINCOLN · PI BECKER, DONALD F, BLACK, PAUL N. · 2015 to 2019
$1.0M
NIAMS NIH HHS R01 AR080926NIGMS NIH HHS P20 GM113126NIGMS NIH HHS T32 GM107001
6 · The paper itself

Abstract

Type I collagen is a predominant fibrous protein that makes up the extracellular matrix. Collagen enhances cell attachment and is commonly used in three-dimensional culture systems, to mimic the native extracellular environment, for primary sensory neurons such as dorsal root ganglia (DRG). However, the effects of collagen concentration on adult rat DRG neurite growth have not been assessed in a physiologically relevant, three-dimensional culture. This study focuses on the effects of type I collagen used in a methacrylated hyaluronic acid (MAHA)-laminin-collagen gel (triple gel) on primary adult rat DRG explants

Indexed as

Collagen Type IHydrogelsAnimalsCells, CulturedCollagenGanglia, SpinalNeuritesNeuronal OutgrowthRatsCollagenCollagen Type IHydrogelsdorsal root gangliaexplantshydrogelsneuronsType I collagen

Identifiers

PMID37847579
PMCPMC11611068
OpenAlexW4387723144

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.