Evidence map›Paper›PMID 37846980›Full record

ArticleInfection and immunity2023

Bulk and single-nucleus RNA sequencing highlight immune pathways induced in individuals during an

Xiaotian Tang, Geoffrey E Lynn, Yingjun Cui, Jiri Cerny, Gunjan Arora, Mary M Tomayko, Joseph Craft, Erol Fikrig

Open access · greenAbstract read
In one paragraph

Article in Infection and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Infection and immunity · 2025
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Xiaotian Tang *Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.ORCID 0000-0002-0171-9354
Geoffrey E Lynn *Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.ORCID 0000-0002-7095-0912
Yingjun Cui *Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.
Jiri CernyCzech University of Life Sciences Prague , Praha-Suchdol, Czechia.
Gunjan AroraSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.
Mary M TomaykoDepartment of Dermatology, Yale University School of Medicine , New Haven, Connecticut, USA.
Joseph CraftSection of Rheumatology, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine , New Haven, Connecticut, USA.ORCID 0000-0002-5884-6047
Yale University · USCzech University of Life Sciences Prague · CZ

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig, UTPAL PAL · 2018 to 2026
$13.5M
The role of tick gut microbiota in Borrelia burgdorferi transmission to miceR01AI126033 · NIAID · YALE UNIVERSITY · PI FIKRIG, EROL, NARASIMHAN, SUKANYA · 2017 to 2020
$1.7M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI126033
6 · The paper itself

Abstract

Ticks are hematophagous arthropods that use a complex mixture of salivary proteins to evade host defenses while taking a blood meal. Little is known about the immunological and physiological consequences of tick feeding on humans. Here, we performed the first bulk and single-nucleus RNA sequencing (snRNA-seq) of skin and blood of four persons presenting with naturally acquired, attached

Indexed as

IxodesTick BitesAnimalsBase SequenceFeeding BehaviorGuinea PigsHumansRNA, Small NuclearRNA, Small Nuclearacquired resistancehumanimmune pathwaysRNA-seqticktick-borne pathogens

Identifiers

PMID37846980
PMCPMC10652856
OpenAlexW4387692515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.