ArticleHuman brain mapping2023
Integration and segregation manifolds in the brain ensure cognitive flexibility during tasks and rest.
Article in Human brain mapping, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Developmental and aging changes in brain network switching dynamics revealed by EEG phase synchronization.PLoS computational biology · 2026Article
- Cognition, but not affect, rests upon a segregated intrinsic network architecture.bioRxiv : the preprint server for biology · 2026Article
- Spontaneous brain regional dynamics contribute to generalizable brain-behaviour associations.Nature human behaviour · 2026Article
- States of dynamic connectivity flow in temporal multiplex networks: A case study in human epilepsy and postictal aphasia.Network neuroscience (Cambridge, Mass.) · 2026Article
- Deep learning and whole-brain networks for biomarker discovery: modeling the dynamics of brain fluctuations in resting-state and cognitive tasks.Scientific reports · 2025Article
- Changing cognitive chimera states in human brain networks with age: Variations in cognitive integration and segregation.PLoS computational biology · 2025Article
- Episode-specific cortical functional connectome reorganization and neurobiological correlates in bipolar disorder: a cross-sectional study.BMC medicine · 2025Article
- Laughter as a Subject and a Tool for Interdisciplinary Investigations in Philosophy and Neuroscience.The European journal of neuroscience · 2025Article
- Dynamic switching between brain networks predicts creative ability.Communications biology · 2025Article
- Graph models of brain state in deep anesthesia reveal sink state dynamics of reduced spatiotemporal complexity.Network neuroscience (Cambridge, Mass.) · 2025Article
- Emergence of multiple spontaneous coherent subnetworks from a single configuration of human connectome coupled oscillators model.Scientific reports · 2024Article
- Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep in humans.Nature communications · 2024Article
- Brain imaging of a gamified cognitive flexibility task in young and older adults.Brain imaging and behavior · 2024Article
- Measuring the dynamic balance of integration and segregation underlying consciousness, anesthesia, and sleep.bioRxiv : the preprint server for biology · 2024Article
- Emergence of metastability in frustrated oscillatory networks: the key role of hierarchical modularity.Frontiers in network physiology · 2024Article
- Integration and segregation manifolds in the brain ensure cognitive flexibility during tasks and rest.Human brain mapping · 2023Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
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Abstract
Adapting to a constantly changing environment requires the human brain to flexibly switch among many demanding cognitive tasks, processing both specialized and integrated information associated with the activity in functional networks over time. In this study, we investigated the nature of the temporal alternation between segregated and integrated states in the brain during rest and six cognitive tasks using functional MRI. We employed a deep autoencoder to explore the 2D latent space associated with the segregated and integrated states. Our results show that the integrated state occupies less space in the latent space manifold compared to the segregated states. Moreover, the integrated state is characterized by lower entropy of occupancy than the segregated state, suggesting that integration plays a consolidating role, while segregation may serve as cognitive expertness. Comparing rest and the tasks, we found that rest exhibits higher entropy of occupancy, indicating a more random wandering of the mind compared to the expected focus during task performance. Our study demonstrates that both transient, short-lived integrated and segregated states are present during rest and task performance, flexibly switching between them, with integration serving as information compression and segregation related to information specialization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.