ArticleJournal of orthopaedic surgery and research2023
Comparison between calcaneus quantitative ultrasound and the gold standard DXA in the ability to detect osteoporosis in chronic obstructive pulmonary disease patients.
Article in Journal of orthopaedic surgery and research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
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12 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Comparative analysis of bone density measurement techniques: a systematic review of quantitative ultrasound and dual-energy X-ray absorptiometry.Frontiers in endocrinology · 2026Pooled it
- Multidirectional Optical Bone Densitometry Using a Simulation-Based Machine Learning Model: Experimental Validation with Bone Phantoms.Annals of biomedical engineering · 2026Article
- Calcaneal quantitative ultrasound parameters strongly correlate with DXA measurements in patients with acromegaly.Pituitary · 2026Observational
- Nomogram for Osteoporosis Risk Using LDCT Trabecular Parameters.Diagnostics (Basel, Switzerland) · 2026Article
- Utilization of Quantitative Ultrasound Methods for Bone Mass Density Measurement in General Population - An Observational Study.Journal of orthopaedic case reports · 2025Article
- Development and validation of an interpretable machine learning model for osteoporosis prediction using routine blood tests: a retrospective cohort study.BMC medical informatics and decision making · 2025Article
- Construction and validation of a multi-dimensional health indicator-driven osteoporosis risk prediction model: a large-sample cross-sectional study based on two centers.BMC musculoskeletal disorders · 2025Article
- Bone Health for Gynaecologists.Medicina (Kaunas, Lithuania) · 2025Review
- Article
- External validation of a deep learning model for predicting bone mineral density on chest radiographs.Archives of osteoporosis · 2024Article
- Association of bone health by calcaneal quantitative ultrasound with quadriceps strength and function one year after unilateral total knee arthroplasty.Journal of orthopaedics · 2024Article
- Correction: Comparison between calcaneus quantitative ultrasound and the gold standard DXA in the ability to detect osteoporosis in chronic obstructive pulmonary disease patients.Journal of orthopaedic surgery and research · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOsteoporosis is a prevalent comorbidity in patients with COPD that is usually underrecognized and hence, undertreated. Compared to the gold standard dual-energy X-ray absorptiometry (DXA), calcaneus quantitative ultrasound (QUS) is less expensive, more portable, and more accessible, especially in less developed countries. The aim of this study was to investigate the ability of calcaneus QUS to screen and prescreen for osteoporosis in patients with COPD.
methodsThis cross-sectional study enrolled 67 males older than 50 years with clinically stable COPD. DXA scans of the lumbar spine (L2-4) and femoral neck were performed. QUS of the right calcaneus (AOS-100) was used to assess the broadband ultrasound attenuation (BUA), speed of sound (SOS), osteo sono-assessment index (OSI), and T-score. When the T-score was ≤ - 2.5, osteoporosis was diagnosed by both DXA and QUS.
resultsForty-eight patients (71.6%) had DXA T-scores ≤ - 2.5 at either the lumbar spine or femoral neck. All QUS parameters (BUA, SOS, OSI, and T-score) could discriminate DXA-determined osteoporosis (the area under the curve varied from 0.64 to 0.83). The QUS T-score was significantly moderately correlated with the DXA T-score at both the femoral neck (r = 0.55) and lumbar spine (r = 0.52). The sensitivity and specificity of QUS in identifying osteoporosis were 10.4% and 94.7%, respectively. The positive and negative predictive values were 83.3% and 29.5%, respectively. When a QUS T-score of 0.09 was used as the cutoff, the sensitivity exceeded 90%, and 15% of the DXA scans were not warranted.
conclusionsThe sensitivity and specificity of calcaneus QUS were not sufficient for QUS to be used as an alternative to DXA for osteoporosis screening. However, QUS may be useful for prescreening before DXA to identify COPD patients who have either a high or low likelihood of osteoporosis. Consequently, QUS reduces the need for DXA referral.
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