ReviewNature aging2023
Navigating and diagnosing cognitive frailty in research and clinical domains.
Review in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- [Effects of exergame combined with elastic band resistance training on exercise self-efficacy and physical activity levels in older adults with cognitive frailty: A mixed-methods study].Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2026Trial
- Cognitive frailty and adverse outcomes in older people with maintenance hemodialysis: a multicenter prospective cohort study.BMC geriatrics · 2026Article
- Unravelling cognitive frailty: perceptions, misconceptions, and the path to prevention.The Gerontologist · 2026Article
- [Analysis of risk factors for postoperative loss of reduction in unstable distal radius fractures and development of a nomogram prediction model].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2026Article
- Associations between cognitive frailty and circulating cardiovascular biomarkers in a memory clinic cohort.GeroScience · 2026Article
- Associations of frailty and cognitive impairment with fall risk in older adults: a longitudinal cohort study based on CHARLS.BMC geriatrics · 2026Article
- Association between cognitive function and all-cause mortality among US older adults with cardiovascular-kidney-metabolic syndrome.BMC geriatrics · 2026Article
- Prevalence and predictive factors of cognitive impairment among hospitalized older adults in iran: a cross-sectional study, 2024.Aging clinical and experimental research · 2026Article
- Four-Limb Coordinated Training and Neuroplasticity in Older Adults with Cognitive Frailty: Mechanisms and Clinical Evidence.Clinical interventions in aging · 2026Review
- Progress in research on cognitive frailty in the older adults: a narrative review.Frontiers in medicine · 2026Review
- Influencing factors of cognitive frailty in older patients with esophageal cancer undergoing chemotherapy: a mixed-methods study.Frontiers in oncology · 2026Article
- Physical activity, home and leisure activities, and neuropsychological performance in middle-aged and older adults living in the community.Health psychology report · 2026Article
- Association Rule Analysis of Cognitive Frailty Subtypes in Community-Dwelling Older Adults.Clinical interventions in aging · 2026Article
- Chronic Kidney disease and cognitive frailty in aging: molecular crosstalk and clinical implications.Frontiers in aging neuroscience · 2026Review
- Exploring Frailty Status and Blood Biomarkers: A Multidimensional Approach to Alzheimer's Diagnosis.Geriatrics (Basel, Switzerland) · 2025Article
- Association between sensory impairment and cognitive frailty among older people: Evidence from four nationwide cohort studies.The journal of nutrition, health & aging · 2025Article
- Single cell RNA sequencing analysis of mice hindlimb muscles identifies transcriptional heterogeneity in aging and physical frailty.Scientific reports · 2025Article
- Bursts of brain erosion: seizures and age-dependent neurological vulnerability.Trends in molecular medicine · 2025Review
- Differential proteomic profiles between cognitive frail and robust older adults from the MELoR cohort.GeroScience · 2025Article
- The value of radiomics features of white matter hyperintensities in diagnosing cognitive frailty: a study based on T2-FLAIR imaging.BMC medical imaging · 2025Article
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
While physical frailty has been recognized as a clinical entity for some time, the concept of cognitive frailty (CF) is now gaining increasing attention in the geriatrics research community. CF refers to the co-occurrence of physical frailty and cognitive impairment in older adults, which has been suggested as a potential precursor to both dementia and adverse physical outcomes. However, this condition represents a challenge for researchers and clinicians, as there remains a lack of consensus regarding the definition and diagnostic criteria for CF, which has limited its utility. Here, using insights from both the physical frailty literature and cognitive science research, we describe emerging research on CF. We highlight areas of agreement as well as areas of confusion and remaining knowledge gaps, and provide our perspective on fine-tuning the current construct, aiming to stimulate further discussion in this developing field.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.