ArticleSkeletal radiology2024
MRI features of benign peripheral nerve sheath tumors: how do sporadic and syndromic tumors differ?
Article in Skeletal radiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Clinical and Imaging Phenotype of Schwannomatosis in Children, Adolescents and Young Adults.Cancers · 2026Article
- Isolated femoral nerve neurofibroma with vastus medialis muscle atrophy as the initial symptom: a case report and literature review.Frontiers in oncology · 2026Article
- Anteromedial Knee Pain Unmasked: Schwannoma of the Infrapatellar Branch of the Saphenous Nerve - A Rare Case Report.Journal of orthopaedic case reports · 2026Article
- Soft Tissue Masses of the Hand.Seminars in musculoskeletal radiology · 2025Review
- Review
- Multiple sporadic schwannomas in a previously radiated field.Radiology case reports · 2024Article
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4 authors.
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Abstract
objectivesTo compare MRI features of sporadic and neurofibromatosis syndrome-related localized schwannomas and neurofibromas.
methodsIn this retrospective study, our pathology database was searched for "neurofibroma" or "schwannoma" from 2014 to 2019. Exclusion criteria were lack of available MRI and intradural or plexiform tumors. Qualitative and quantitative anatomic (location, size, relationship to nerve, signal, muscle denervation) and functional (arterial enhancement, apparent diffusion-weighted coefficient) MRI features of sporadic and syndrome-related tumors were compared. Statistical significance was assumed for p < 0.05.
resultsA total of 80 patients with 64 schwannomas (sporadic: 42 (65.6%) v. syndrome-related: 22 (34.4%)) and 19 neurofibromas (sporadic: 7 (36.8%) v. syndrome-related: 12 (41.7%)) were included. Only signal heterogeneity (T2W p=0.001, post-contrast p=0.03) and a diffused-weighted imaging target sign (p=0.04) were more frequent with schwannomas than neurofibromas. Sporadic schwannomas were similar in size to syndrome-related schwannomas (2.9±1.2cm vs. 3.7±3.2 cm, p = 0.6), but with greater heterogeneity (T2W p = 0.02, post-contrast p = 0.01). Sporadic neurofibromas were larger (4.6±1.5cm vs. 3.4±2.4 cm, p = 0.03) than syndrome-related neurofibromas, also with greater heterogeneity (T2W p=0.03, post-contrast p=0.04). Additional tumors along an affected nerve were only observed with syndrome-related tumors). There was no difference in apparent diffusion coefficient values or presence of early perfusion between sporadic and syndrome-related tumors (p > 0.05).
conclusionsAlthough syndrome-related and sporadic schwannomas and neurofibromas overlap in their anatomic, diffusion and perfusion features, signal heterogeneity and presence of multiple lesions along a nerve are differentiating characteristics of syndrome-related tumors.
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