Evidence map›Paper›PMID 37845440›Full record

ArticleAdvances in experimental medicine and biology2023

Cerebral Net Water Uptake in Posttraumatic Cerebral Ischemia.

Alex O Trofimov, Kseniia A Trofimova, Kyril Lidji-Goryaev, Dmitry Martynov, Edwin Nemoto, Olga A Bragina, Denis E Bragin

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In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Kseniia A TrofimovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Kyril Lidji-GoryaevDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Dmitry MartynovTechnical State University Named After RE Alexeev, Nizhny Novgorod, Russia.
Edwin NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Olga A BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Denis E BraginDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

We assessed net water uptake changes (NWU) in regions of posttraumatic ischemia in relation to cerebral microcirculation mean transit time (MTT) at moderate-to-severe traumatic brain injury (TBI). MATERIALS AND

methods128 moderate-to-severe traumatic brain injury patients (44 women, 84 men, age: 37 ± 12 years) were stratified into 3 groups: Marshall 2-3: 48 patients, Marshall 4: 44 patients, Marshall 5: 36 patients. The groups were matched by sex and age. Patients received multiphase perfusion computed tomography (PCT) 1-5 days after admission. Net water uptake was calculated from non-contrast computed tomography. Data are shown as a median [interquartile range]. P < 0.05 was considered statistically significant.

resultsCerebral blood flow in posttraumatic ischemia foci in Marshall 4 group was significantly higher than that in the Marshall 5 group (p = 0.027). Net water uptake in posttraumatic ischemia zones was significantly higher than in zones without posttraumatic ischemia (8.1% versus 4.2%, p < 0.001). Mean transit time in posttraumatic ischemia zones was inversely and significantly correlated with higher net water uptake (R

conclusionsDelay of blood flow through the cerebral microvascular bed was significantly correlated with the increased net water uptake in posttraumatic ischemia foci. Marshall's classification did not predict the progression of posttraumatic ischemia.

Indexed as

Brain Injuries, TraumaticBrain IschemiaAdultCerebrovascular CirculationFemaleHemodynamicsHumansIschemiaMaleMiddle AgedTomography, X-Ray ComputedCerebral blood flowNet water uptakeTraumatic brain injury

Identifiers

PMID37845440
PMCPMC11351295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.