Evidence map›Paper›PMID 37845438›Full record

ArticleAdvances in experimental medicine and biology2023

Mechanisms of Photostimulation of Brain's Waste Disposal System: The Role of Singlet Oxygen.

Oxana Semyachkina-Glushkovskaya, Denis Bragin, Ivan Fedosov, Inna Blokhina, Alexander Khorovodov, Andrey Terskov, Alexander Shirokov, Alexander Dubrovsky, Valeria Vinnik, Arina Evsukova and 13 more

Open access · greenAbstract read
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In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 4 institutions in 4 countries.

Oxana Semyachkina-GlushkovskayaPhysics Department, Humboldt University, Berlin, Germany.
Denis BraginLovelace Biomedical Research Institute, Albuquerque, NM, USA. dbragin@lrri.org.
Ivan FedosovDepartment of Biology, Saratov State University, Saratov, Russia.
Inna BlokhinaDepartment of Biology, Saratov State University, Saratov, Russia.
Alexander KhorovodovDepartment of Biology, Saratov State University, Saratov, Russia.
Andrey TerskovDepartment of Biology, Saratov State University, Saratov, Russia.
Alexander ShirokovDepartment of Biology, Saratov State University, Saratov, Russia.
Alexander DubrovskyDepartment of Biology, Saratov State University, Saratov, Russia.
Valeria VinnikDepartment of Biology, Saratov State University, Saratov, Russia.
Arina EvsukovaDepartment of Biology, Saratov State University, Saratov, Russia.
Daria ElovenkoDepartment of Biology, Saratov State University, Saratov, Russia.
Viktoria AdushkinaDepartment of Biology, Saratov State University, Saratov, Russia.
Maria TzoyDepartment of Biology, Saratov State University, Saratov, Russia.
Alexander DmitrenkoDepartment of Biology, Saratov State University, Saratov, Russia.
Valeria KrupnovaDepartment of Biology, Saratov State University, Saratov, Russia.
Maria ManzhaevaDepartment of Biology, Saratov State University, Saratov, Russia.
Ilana AgranovichDepartment of Biology, Saratov State University, Saratov, Russia.
Elena SarancevaDepartment of Biology, Saratov State University, Saratov, Russia.
Tatyana IskraDepartment of Biology, Saratov State University, Saratov, Russia.
Ekaterina LykovaDepartment of Biology, Saratov State University, Saratov, Russia.
Sergey SokolovskiOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham, UK.
Edik RafailovOptoelectronics and Biomedical Photonics Group, AIPT, Aston University, Birmingham, UK.
Jürgen KurthsPhysics Department, Humboldt University, Berlin, Germany.
Saratov State University · RUAston University · GBHumboldt-Universität zu Berlin · DEUniversity of New Mexico · US

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808
6 · The paper itself

Abstract

There is strong evidence that augmentation of the brain's waste disposal system via stimulation of the meningeal lymphatics might be a promising therapeutic target for preventing neurological diseases. In our previous studies, we demonstrated activation of the brain's waste disposal system using transcranial photostimulation (PS) with a laser 1267 nm, which stimulates the direct generation of singlet oxygen in the brain tissues. Here we investigate the mechanisms underlying this phenomenon. Our results clearly demonstrate that PS-mediated stimulation of the brain's waste disposal system is accompanied by activation of lymphatic contractility associated with subsequent intracellular production of the reactive oxygen species and the nitric oxide underlying lymphatic relaxation. Thus, PS stimulates the brain's waste disposal system by influencing the mechanisms of regulation of lymphatic pumping.

Indexed as

BrainSinglet OxygenMeningesNitric OxideReactive Oxygen SpeciesNitric OxideReactive Oxygen SpeciesSinglet OxygenBrain’s waste disposal systemMeningeal lymphaticsPhotostimulationSinglet oxygen

Identifiers

PMID37845438
PMCPMC11349324
OpenAlexW4387681923

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.