Evidence map›Paper›PMID 37845431›Full record

ArticleAdvances in experimental medicine and biology2023

Brain Tissue Oxygen and BOLD fMRI Under Different Levels of Neuronal Activity.

D P Aksenov, K Rutila, L Li, M J Miller, D A Gascoigne, N A Serdyukova, E D Doubovikov, R A Linsenmeier, A Drobyshevsky

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

D P AksenovDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA. daksenov@northshore.org.
K RutilaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
L LiDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
M J MillerDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
D A GascoigneDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
N A SerdyukovaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
E D DoubovikovDepartment of Radiology, NorthShore University HealthSystem, Evanston, IL, USA.
R A LinsenmeierDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
A DrobyshevskyUniversity of Chicago, Pritzker School of Medicine, Chicago, IL, USA.
NorthShore University HealthSystem · USNorthwestern University · US

Funding

Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposureR01GM112715 · NIGMS · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI AKSENOV, DANIIL · 2016 to 2024
$3.0M
Role of interneurons in brain tissue oxygen regulationR01NS107383 · NINDS · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI Daniil Aksenov · 2018 to 2026
$2.4M
Role of interneurons in resting state fMRI connectivity during normal development and after perinatal brain injuryR01NS119251 · NINDS · ENDEAVOR HEALTH CLINICAL OPERATIONS · PI DROBYSHEVSKY, ALEXANDER · 2021 to 2024
$1.8M
NIGMS NIH HHS R01 GM112715NINDS NIH HHS R01 NS107383NINDS NIH HHS R01 NS119251
6 · The paper itself

Abstract

Localized increases in neuronal activity are supported by the hemodynamic response, which delivers oxygen to the brain tissue to support synaptic functions, action potentials and other neuronal processes. However, it remains unknown if changes in baseline neuronal activity, which are expected to reflect neuronal metabolic demand, alter the relationship between the local hemodynamic and oxygen behaviour. In order to better characterize this system, we examine here the relationship between brain tissue oxygen (PO

Indexed as

IsofluraneOxygenBrainHemodynamicsMagnetic Resonance ImagingIsofluraneOxygenanaesthesiaBOLD responseBrain tissue oxygenation

Identifiers

PMID37845431
PMCPMC11259030
OpenAlexW4387681853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.