ArticleMolecular genetics and genomics : MGG2023
Assessing the causal relationship between immune traits and systemic lupus erythematosus by bi-directional Mendelian randomization analysis.
Article in Molecular genetics and genomics : MGG, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 48 citations in OpenAlex.
- Genetically determined causality between immune cells and anxiety disorders: A Mendelian randomization study.Medicine · 2026Article
- Integrative mendelian randomization approaches for therapeutic target prioritisation in immune-mediated diseases.Scientific reports · 2026Article
- Genetic insights into colorectal cancer pathogenesis: a multi-omics and immunity perspective.Translational cancer research · 2025Article
- Identification the correlation between hip and knee osteoarthritis and their causal relationship with immune traits.BMC musculoskeletal disorders · 2025Article
- Causal association between immune cytokines and psoriasis: A two-way Mendelian randomization study.Medicine · 2025Article
- Causal analysis of 731 immunophenotypes and heart failure: A bidirectional Mendelian randomization study.Medicine · 2025Article
- Causal role of immune cells in male infertility: a Mendelian randomization study.Translational andrology and urology · 2025Article
- A Mendelian randomization study: causal relationship between immune cells and the risks of social phobia, specific phobia, and agoraphobia.BMC psychiatry · 2025Article
- Assessing the causal association between 731 immunophenotypes and the risk of colorectal cancer: a Mendelian randomization study.BMC cancer · 2025Article
- Genetically predicted circulating immune cells and cytokines reveal the causal role of immune factors on female infertility: a two-sample mendelian randomization study.BMC pregnancy and childbirth · 2025Article
- Mutual causal effects between immune cells and hepatocellular carcinoma: a Mendelian randomization study.Discover oncology · 2025Article
- Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study.Clinical, cosmetic and investigational dermatology · 2025Article
- Decoding Immune Influence: A Mendelian Randomisation Study on Dilated Cardiomyopathy.European cardiology · 2025Article
- Genetically predicted immune cells mediate the association between gut microbiota and neuropathy pain.Inflammopharmacology · 2024Article
- Causal Relationships between Circulating Immune Cell Traits and the Risk of Rheumatoid Arthritis and Osteoarthritis: A Bidirectional Two-Sample Mendelian Randomization Study.Iranian journal of public health · 2024Article
- Integrative Analysis by Mendelian Randomization and Large-Scale Single-Cell Transcriptomics Reveals Causal Links between B Cell Subtypes and Diabetic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2024Article
- Causal relationship between circulating immune cells and gastric cancer: a bidirectional Mendelian randomization analysis using UK Biobank and FinnGen datasets.Translational cancer research · 2024Article
- Causal role of immune cells in aplastic anemia: Mendelian randomization (MR) study.Scientific reports · 2024Article
- Revealing an association between HPV and systemic lupus erythematosus: A bidirectional two-sample Mendelian randomization study.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024Article
- Causal role of immune cells in chronic periodontitis: a bidirectional Mendelian randomization study.BMC oral health · 2024Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have observed relationships between immune cells and systemic lupus erythematosus (SLE), but their causal links remain undetermined. Based on the public available genome-wide association studies (GWAS) summary statistics, we conducted two-sample Mendelian randomization (MR) to evaluate the associations between 731 immune phenotypes and SLE pairs. Pairwise pleiotropy analysis was performed to identify pleiotropic genes for significant immunophenotype-SLE pairs. A comprehensive gene function analysis was undertaken to explore the mechanisms of immune cells in SLE. By using the instrumental variables extracted from GWAS data, we observed that increased levels of five immune phenotypes were causally associated with SLE risk (FDR < 0.05), that were CD20 on IgD
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.