Evidence map›Paper›PMID 37845314›Full record

ReviewNature microbiology2023

SARS-CoV-2 evolution in the Omicron era.

Cornelius Roemer, Daniel J Sheward, Ryan Hisner, Federico Gueli, Hitoshi Sakaguchi, Nicholas Frohberg, Josette Schoenmakers, Kenta Sato, Áine O'Toole, Andrew Rambaut and 4 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed.

  1. Article
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  9. Review
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  19. A Pandemic-Scale Ancestral Recombination Graph for SARS-CoV-2.bioRxiv : the preprint server for biology · 2025
    Article
  20. Article

19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Cornelius RoemerBiozentrum, University of Basel, Basel, Switzerland.ORCID 0000-0002-6138-6539
Daniel J ShewardDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0227-5636
Ryan HisnerUniversity of Cape Town, Rondebosch, South Africa.ORCID 0000-0001-8296-9373
Federico GueliIndependent researcher, Como, Italy.
Hitoshi SakaguchiIndependent researcher, Yotsukaido City, Japan.
Nicholas FrohbergIndependent researcher, Madison, WI, USA.
Josette SchoenmakersIndependent researcher, Haarlem, The Netherlands.
Kenta SatoDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Áine O'TooleInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0001-8083-474X
Andrew RambautInstitute of Ecology and Evolution, University of Edinburgh, Edinburgh, UK.ORCID 0000-0003-4337-3707
Oliver G PybusDepartment of Biology, University of Oxford, Oxford, UK.
Christopher RuisMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge, UK.ORCID 0000-0003-0977-5534
Ben MurrellDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-0393-4445
Thomas P PeacockDepartment of Infectious Disease, Imperial College London, London, UK. tpp09@ic.ac.uk.ORCID 0000-0001-7077-2928

Funding

Familjen Erling-Perssons Stiftelse (Erling-Persson Family Foundation) ID: 2021 0125RCUK | Medical Research Council (MRC) MR/W005611/1Science for Life Laboratory (SciLifeLab) VC-2022-0028 and VC-2021-0033
6 · The paper itself

Abstract

Since SARS-CoV-2 BA.5 (Omicron) emerged and spread in 2022, Omicron lineages have markedly diversified. Here we review the evolutionary trajectories and processes that underpin the emergence of these lineages, and identify the most prevalent sublineages. We discuss the potential origins of second-generation BA.2 lineages. Simple and complex recombination, antigenic drift and convergent evolution have enabled SARS-CoV-2 to accumulate mutations that alter its antigenicity. We also discuss the potential evolutionary trajectories of SARS-CoV-2 in the future.

Indexed as

COVID-19HumansMutationSARS-CoV-2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.