Evidence map›Paper›PMID 37845281›Full record

ArticleScientific reports2023

Screening of the antileishmanial and antiplasmodial potential of synthetic 2-arylquinoline analogs.

Roger Espinosa-Saez, Sara M Robledo, Tatiana Pineda, Javier Murillo, César Zúñiga, Osvaldo Yañez, Plinio Cantero-López, Alex Saez-Vega, Camilo Guzmán-Teran

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Exploring Quinoline Derivatives: Their Antimalarial Efficacy and Structural Features.Medicinal chemistry (Shariqah (United Arab Emirates)) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Roger Espinosa-SaezGrupo de Investigación, Evaluación y Desarrollo de Fármacos y Afines-IDEFARMA, Departamento de Regencia y Farmacia, Universidad de Córdoba, Montería, Córdoba, Colombia.
Sara M RobledoPrograma de Estudio y Control de Enfermedades Tropicales-PECET, Facultad de Medicina, Universidad de Antioquia, Medellín, Antioquia, Colombia.
Tatiana PinedaCorporación de Innovación Para el Desarrollo de Productos, Medellín, Antioquia, Colombia.
Javier MurilloCorporación de Innovación Para el Desarrollo de Productos, Medellín, Antioquia, Colombia.
César ZúñigaInstituto de Ciencias Naturales, Facultad de Medicina Veterinaria y Agronomía, Universidad de Las Américas, Sede Providencia, Santiago, Chile.
Osvaldo YañezNúcleo de Investigación en Data Science, Facultad de Ingeniería y Negocios, Universidad de las Américas, Santiago, Chile.
Plinio Cantero-LópezDepartamento de Ciencias, Facultad de Ciencias Exactas, Químicas, Universidad Andres Bello, Viña del Mar, Chile.
Alex Saez-VegaEscuela de Ciencias Aplicadas e Ingenierías, Universidad EAFIT, Medellín, Colombia.
Camilo Guzmán-TeranGrupo de Investigación, Evaluación y Desarrollo de Fármacos y Afines-IDEFARMA, Departamento de Regencia y Farmacia, Universidad de Córdoba, Montería, Córdoba, Colombia. cantonioguzman@correo.unicordoba.edu.co.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, six analogs of 2-arylquinoline were synthesized and evaluated for their in vitro and in vivo antiplasmodial and leishmanicidal activity. At a later stage, hemolytic activity and druggability were tested in vitro and in silico, respectively, observing as a result: firstly, compounds showed half-maximal effective concentration (EC

Indexed as

AntimalarialsAntiprotozoal AgentsLeishmaniaAnimalsMolecular Docking SimulationStructure-Activity RelationshipAntimalarialsAntiprotozoal Agents

Identifiers

PMID37845281
PMCPMC10579228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.