Evidence map›Paper›PMID 37844954›Full record

ArticleNeurosciences (Riyadh, Saudi Arabia)2023

The role of MicroRNA as a potential diagnostic and prognostic biomarker for cerebral aneurysms.

Hosam M Al-Jehani, Alaa N Turkistani, Majd M Alrayes, May A AlHamid, Arwa S AlShamikh, Zhra M Al Sadah, Faisal M Alabbas, Cyril Cyrus, Amein K Al-Ali

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Article in Neurosciences (Riyadh, Saudi Arabia), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Epigenetic mechanisms in aneurysm formation, growth, and rupture: A systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hosam M Al-JehaniFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.ORCID https://orcid.org/0000-0002-3830-9789
Alaa N TurkistaniFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Majd M AlrayesFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
May A AlHamidFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Arwa S AlShamikhFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Zhra M Al SadahFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Faisal M AlabbasFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Cyril CyrusFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.
Amein K Al-AliFrom the Department of Neurosurgery (Al-Jehani), Interventional Neuroradiology and Critical Care Medicine, Department of Neurology (AlHamid, Alabbas), King Fahad Hospital of the University, Imam Abdulrahman bin Faisal University, AL Khobar, from the College of Medicine (Alrayes, Al Sadah), Imam Abdulrahman bin Faisal University, Department of Biochemistry (Cyrus, Al-Ali), College of Medicine, Imam Abdulrahman bin Faisal University, Dammam, and from the Department of Neurosurgery (Turkistani), King Faisal Specialist Hospital and Research Center, and from the Department of Neurosurgery (AlShamikh), National Neuroscience Institute, King Fahad Medical City Riyadh, Kingdom of Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify the dysregulated functional miRNAs, miRNA-16, miRNA-143, and miRNA-200 as potential biomarkers of cerebral aneurysms(CAs) to aid in diagnosis and prognosis.

methodsThis is a prospective case-control study conducted among patients with CA. All patients' computed tomography angiography (CTA) and interventional angiogram were assessed and studied. The miRNAs were isolated and quantified from peripheral blood samples and the expression profiling was done using TaqMan chemistry on Real-Time PCR.

resultsA total of 37 samples were included. Three cases had double aneurysms and 10 cases presented with aneurysmal rupture. miRNA-16, miRNA-143, and miRNA-200 were upregulated with an absolute fold-change of >8 in the CA group in comparison to controls (

conclusionmiRNA-16, miRNA-143, and miRNA-200 showed statically significant higher expression among cases with cerebral aneurysms in comparison to controls. Thus, these preliminary results of miRNAs biomarkers are promising future tool to be used for aneurysmal screening.

Indexed as

Intracranial AneurysmMicroRNAsBiomarkersCase-Control StudiesHumansPrognosisBiomarkersMicroRNAsMIRN16 microRNA, humanMIRN200 microRNA, human

Identifiers

PMID37844954
PMCPMC10827034
OpenAlexW4387675085

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