Evidence map›Paper›PMID 37844787›Full record

ArticlePhotodiagnosis and photodynamic therapy2024

Painless photodynamic therapy for facial actinic keratoses: A retrospective cohort study of the post-treatment inflammatory response.

Alan S Shen, Lauren E Heusinkveld, Abigail Updyke, Amy S Nowacki, Christine B Warren, Edward V Maytin

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photodiagnosis and photodynamic therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Alan S ShenCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Lauren E HeusinkveldCleveland Clinic Lerner College of Medicine of Case Western Reserve University, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Abigail UpdykeDepartment of Biomedical Engineering, Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA.
Amy S NowackiDepartment of Quantitative Health Sciences; Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA.
Christine B WarrenDepartment of Dermatology, Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
Edward V MaytinDepartment of Dermatology, Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA; Department of Biomedical Engineering, Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA; Department of Quantitative Health Sciences; Cleveland Clinic, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, USA; Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Desk A60, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA. Electronic address: maytine@ccf.org.
Cleveland Clinic Lerner College of Medicine · USCleveland Clinic · USCase Western Reserve University · US

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
Vitamin D and Photodynamic Therapy for Human Skin Cancer (SCC and BCC)R01CA204158 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI MAYTIN, EDWARD V · 2017 to 2022
$2.3M
NCI NIH HHS P01 CA084203NCI NIH HHS R01 CA204158
6 · The paper itself

Abstract

introductionPhotodynamic therapy (PDT) is a safe, non-mutagenic, and non-scarring treatment for actinic keratoses (AK).

background'Painless' photodynamic therapy (p-PDT) is a regimen for AK that employs simultaneous aminolevulinate incubation and blue light illumination. The efficacy of p-PDT resembles that of traditional PDT, but detailed mechanisms of action for p-PDT are not well understood.

methodsTo characterize the inflammatory effects of the p-PDT procedure 48 h following treatment and determine the association of inflammation with precancer burden, we performed a retrospective cohort study of 104 patients with AK of face or scalp treated with p-PDT between 2017 and 2019. Patients self-reported their side effects 48 h following p-PDT and took photographs of their face and scalp. Photographs were edited to define seven anatomic regions, and erythema was scored by four investigators.

resultsNinety-eight patients provided photographs suitable for erythema evaluation. Most patients experienced 2 or more side effects and some pain 48 h post-procedure. Females experienced more pain (p = 0.01) and side effects (p = 0.002) compared to males. AK burden was positively associated with post p-PDT erythema response (p < 0.0001) at all sites, but particularly in the temples (p = 0.002) and supralabial area (p = 0.009). DISCUSSION: This study confirms a strong clinical inflammatory response after p-PDT. Severity of inflammation is positively associated with AK tumor burden, suggesting that post-treatment inflammation may be a pre-requisite for p-PDT efficacy. Interestingly, the results also identify certain gender-related differences in the severity of side effects experienced by patients post-PDT.

Indexed as

Keratosis, ActinicPhotochemotherapyErythemaFemaleHumansInflammationMalePainPhotosensitizing AgentsRetrospective StudiesScalpPhotosensitizing Agentsactinic keratosisclinical researchinflammationoncologyPainPhotodynamic therapyphototherapyskin cancertherapeutics

Identifiers

PMID37844787
PMCPMC10922787
OpenAlexW4387639241

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.