Evidence map›Paper›PMID 37844278›Full record

ReviewJournal of immunology (Baltimore, Md. : 1950)2023

Noncanonical B Cells: Characteristics of Uncharacteristic B Cells.

Karen M Haas

Open access · greenAbstract readReview
In one paragraph

Review in Journal of immunology (Baltimore, Md. : 1950), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Do human B-1 lymphocytes truly exist?Frontiers in immunology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Breg-Mediated Immunoregulation in the Skin.International journal of molecular sciences · 2024
    Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Karen M HaasDepartment of Microbiology and Immunology, Wake Forest University School of Medicine, Winston-Salem, NC.ORCID 0000-0002-9951-1964
Wake Forest University · US

Funding

THE IMPACT OF ADVANCED AGE AND SEX ON HUMORAL IMMUNITY TO STREPTOCOCCUS PNEUMONIAER01AI164489 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAAS, KAREN M · 2022 to 2025
$2.1M
Leveraging B cell specificities for tumor glycans to elicit potent anti-tumor immunityR01CA272724 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Karen M Haas · 2022 to 2026
$2.1M
Regulation of Memory B Cell Responses to Polysaccharide AntigensR01AI118876 · NIAID · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI HAAS, KAREN M · 2015 to 2019
$1.9M
NCI NIH HHS R01 CA272724NIAID NIH HHS R01 AI118876NIAID NIH HHS R01 AI164489
6 · The paper itself

Abstract

B lymphocytes were originally described as a cell type uniquely capable of secreting Abs. The importance of T cell help in Ab production was revealed soon afterward. Following these seminal findings, investigators made great strides in delineating steps in the conventional pathway that B cells follow to produce high-affinity Abs. These studies revealed generalized, or canonical, features of B cells that include their developmental origin and paths to maturation, activation, and differentiation into Ab-producing and memory cells. However, along the way, examples of nonconventional B cell populations with unique origins, age-dependent development, tissue localization, and effector functions have been revealed. In this brief review, features of B-1a, B-1b, marginal zone, regulatory, killer, NK-like, age-associated, and atypical B cells are discussed. Emerging work on these noncanonical B cells and functions, along with the study of their significance for human health and disease, represents an exciting frontier in B cell biology.

Indexed as

B-LymphocytesT-LymphocytesHumansLymphoid Tissue

Identifiers

PMID37844278
PMCPMC10593487
OpenAlexW4387686230

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.