Evidence map›Paper›PMID 37844236›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir.

Mithra R Kumar, Emily J Fray, Alexandra M Bender, Carolin Zitzmann, Ruy M Ribeiro, Alan S Perelson, Dan H Barouch, Janet D Siliciano, Robert F Siliciano

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Mithra R Kumar *Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0001-8361-7935
Emily J Fray *Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-5850-6237
Alexandra M BenderDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Carolin ZitzmannLos Alamos National Laboratory, Los Alamos, NM 87545.
Ruy M RibeiroLos Alamos National Laboratory, Los Alamos, NM 87545.ORCID 0000-0002-3988-8241
Alan S PerelsonLos Alamos National Laboratory, Los Alamos, NM 87545.ORCID 0000-0002-2455-0002
Dan H BarouchCenter for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA 02215.
Janet D SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.
Robert F SilicianoDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205.ORCID 0000-0002-1764-1993
Johns Hopkins University · USLos Alamos National Laboratory · USBeth Israel Deaconess Medical Center · US

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Anna Palmer Durbin · 2012 to 2026
$67.0M
BEAT-HIV: Delaney Collaboratory to Cure HIV-1 Infection by Combination ImmunotherapyUM1AI164570 · NIAID · WISTAR INSTITUTE · PI Luis J Montaner, James L. Riley · 2021 to 2026
$34.7M
Reversing Immune Dysfunction for HIV-1 EradicationUM1AI164561 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI SUMIT K CHANDA, Paula M Cannon · 2021 to 2026
$30.0M
I4C 2.0: Immunotherapy for CureUM1AI164556 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Dan H. Barouch, John W Mellors · 2021 to 2026
$28.0M
Delaney AIDS Research Enterprise to Cure HIVUM1AI126611 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DEEKS, STEVEN GRANT, PICKER, LOUIS J. · 2016 to 2020
$27.9M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Combined Immunologic Approaches to Cure HIV-1UM1AI126603 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI BAROUCH, DAN H., MELLORS, JOHN W · 2016 to 2020
$23.6M
Project 2U19AI128751 · NIAID · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ALTER, GALIT · 2018 to 2022
$14.0M
Understanding reservoir dynamics through analysis of viral decay processesP01AI169615 · NIAID · JOHNS HOPKINS UNIVERSITY · PI ALAN S PERELSON · 2022 to 2026
$9.5M
Harnessing IL-10 in cART treated SIV infected macaques to restore immunity and to eradicate HIVR37AI141258 · NIAID · EMORY UNIVERSITY · PI Rafick Pierre Sekaly · 2018 to 2026
$7.8M
Modeling Viral and T Lymphocyte DynamicsR01OD011095 · OD · TRIAD NATIONAL SECURITY, LLC · PI PERELSON, ALAN S · 2012 to 2024
$5.0M
Modeling the HIV latent reservoir, latency reversal and immunotherapeutics for HIV cureR01AI152703 · NIAID · TRIAD NATIONAL SECURITY, LLC · PI KE, RUIAN · 2020 to 2024
$3.0M
NIAID NIH HHS P01 AI169615NIAID NIH HHS P30 AI094189NIAID NIH HHS R01 AI152703NIAID NIH HHS R37 AI141258NIAID NIH HHS U01 AI186993NIAID NIH HHS U19 AI128751NIAID NIH HHS UM1 AI126603NIAID NIH HHS UM1 AI126611NIAID NIH HHS UM1 AI126620NIAID NIH HHS UM1 AI164556NIAID NIH HHS UM1 AI164561NIAID NIH HHS UM1 AI164570NIDCD NIH HHS R21 DC011095NIH HHS R01 OD011095ODCDC CDC HHS R01 OD011095
6 · The paper itself

Abstract

The latent reservoir for HIV-1 in resting CD4

Indexed as

HIV-1HIV InfectionsSimian Acquired Immunodeficiency SyndromeSimian Immunodeficiency VirusAnimalsAnti-Retroviral AgentsCD4-Positive T-LymphocytesHumansMacaca mulattaProvirusesViral LoadVirus ReplicationAnti-Retroviral AgentsHIVIPDAlatent reservoirSHIV

Identifiers

PMID37844236
PMCPMC10614214
OpenAlexW4387665118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.