Evidence map›Paper›PMID 37844228›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2023

Ciliary localization of a light-activated neuronal GPCR shapes behavior.

Amy M Winans, Drew Friedmann, Cherise Stanley, Tong Xiao, Tsung-Li Liu, Christopher J Chang, Ehud Y Isacoff

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Ciliary localization of a light-activated neuronal GPCR shapes behavior.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Amy M WinansDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Drew FriedmannDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Cherise StanleyDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.
Tong XiaoDepartment of Chemistry, University of California, Berkeley, CA 94720.
Tsung-Li LiuHHMI, Janelia Research Campus, Ashburn, VA 20147.
Christopher J ChangDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0001-5732-9497
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California, Berkeley, CA 94720.ORCID 0000-0003-4775-9359
University of California, Berkeley · USJanelia Research Campus · USLawrence Berkeley National Laboratory · US

Funding

Molecular Imaging Probes To Study Redox BiologyR01GM079465 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI Christopher J. Chang · 2006 to 2026
$7.8M
Conformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6M
Optogenetic Vision RestorationR01EY028240 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI FLANNERY, JOHN GERARD, ISACOFF, EHUD · 2018 to 2021
$1.6M
Sensing light through a ciliary non-visual opsin in the developing vertebrate spinal cordF32NS100387 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WINANS, AMY M · 2017 to 2019
$179k
NEI NIH HHS R01 EY028240NIGMS NIH HHS R01 GM079465NINDS NIH HHS F32 NS100387NINDS NIH HHS R01 NS119826
6 · The paper itself

Abstract

Many neurons in the central nervous system produce a single primary cilium that serves as a specialized signaling organelle. Several neuromodulatory G-protein-coupled receptors (GPCRs) localize to primary cilia in neurons, although it is not understood how GPCR signaling from the cilium impacts circuit function and behavior. We find that the vertebrate ancient long opsin A (VALopA), a G

Indexed as

Receptors, G-Protein-CoupledZebrafishAnimalsCiliaNeuronsOpsinsRod OpsinsSignal TransductionOpsinsReceptors, G-Protein-CoupledRod Opsinscentral pattern generatorciliumopsinVALopAzebrafish

Identifiers

PMID37844228
PMCPMC10614621
OpenAlexW4387665117

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.