Evidence map›Paper›PMID 37844105›Full record

ArticleJournal of proteome research2023

Identification of LMAN1- and SURF4-Dependent Secretory Cargoes.

Vi T Tang, Prabhodh S Abbineni, Felipe da Veiga Leprevost, Venkatesha Basrur, Rami Khoriaty, Brian T Emmer, Alexey I Nesvizhskii, David Ginsburg

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Endothelial Cell Secretome Alterations Induced by Inflammatory Stress.bioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Genetics of hemostasis: from bedside to bench and back again.The Journal of clinical investigation · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Vi T TangDepartment of Molecular and Integrative Physiology and Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0001-6079-9756
Prabhodh S AbbineniLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
Felipe da Veiga LeprevostDepartment of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Venkatesha BasrurDepartment of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.
Rami KhoriatyDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Brian T EmmerDepartment of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States.
Alexey I NesvizhskiiDepartment of Pathology, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID 0000-0002-2806-7819
David GinsburgLife Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States.
University of Michigan · USHoward Hughes Medical Institute · USLoyola University Chicago · US

Funding

COMPUTATIONAL TOOLS FOR MASS SPECTROMETRY-BASED INTERACTOME DATAR01GM094231 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 2010 to 2026
$5.4M
The molecular pathophysiology of the congenital dyserythropoietic anemiasR01HL148333 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Rami Khoriaty · 2019 to 2026
$4.6M
The Molecular Genetics of HemostasisR35HL135793 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GINSBURG, DAVID · 2017 to 2023
$4.1M
The regulation of thrombopoietin levelsR01HL157062 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KHORIATY, RAMI · 2021 to 2024
$2.1M
Cholesterol regulation by the cargo receptor SURF4K08HL148552 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI EMMER, BRIAN T · 2019 to 2023
$788k
Examining Molecular Regulation of Unconventional Cytoplasmic Protein SecretionR00GM141268 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI ABBINENI, PRABHODH SAI · 2023 to 2025
$747k
Examining Molecular Regulation of Unconventional Cytoplasmic Protein SecretionK99GM141268 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ABBINENI, PRABHODH SAI · 2021 to 2022
$200k
NHLBI NIH HHS K08 HL148552NHLBI NIH HHS R01 HL148333NHLBI NIH HHS R01 HL157062NHLBI NIH HHS R35 HL135793NIGMS NIH HHS K99 GM141268NIGMS NIH HHS R00 GM141268NIGMS NIH HHS R01 GM094231
6 · The paper itself

Abstract

Most proteins secreted into the extracellular space are first recruited from the endoplasmic reticulum into coat protein complex II (COPII)-coated vesicles or tubules that facilitate their transport to the Golgi apparatus. Although several secreted proteins have been shown to be actively recruited into COPII vesicles and tubules by the cargo receptors LMAN1 and SURF4, the full cargo repertoire of these receptors is unknown. We now report mass spectrometry analysis of conditioned media and cell lysates from HuH7 cells CRISPR targeted to inactivate the

Indexed as

Carrier ProteinsEndoplasmic ReticulumMembrane ProteinsGolgi ApparatusHumansProtein TransportCarrier ProteinsMembrane ProteinsSURF4 protein, humancargo receptorCOPII traffickingsecretome

Identifiers

PMID37844105
PMCPMC10629478
OpenAlexW4387665784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.