Evidence map›Paper›PMID 37844097›Full record

Observational studyPloS one2023

Association of urinary sex hormones with mood and behavior changes in a community adolescent cohort.

Philip Hazell, Ben W R Balzer, Frances Garden, David J Handelsman, Karen Paxton, Catherine Hawke, Rebecca Ivers, S Rachel Skinner, Georgina Luscombe, Katharine S Steinbeck

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Philip HazellFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
Ben W R BalzerFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.ORCID 0000-0001-7116-2339
Frances GardenIngham Institute for Medical Research, The University of New South Wales, Liverpool, NSW, Australia.
David J HandelsmanFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
Karen PaxtonFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
Catherine HawkeFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
Rebecca IversThe University of New South Wales Faculty of Medicine, School of Public Health and Community Medicine, Kensington, NSW, Australia.
S Rachel SkinnerFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
Georgina LuscombeFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.ORCID 0000-0002-4767-5131
Katharine S SteinbeckFaculty of Medicine and Health, The University of Sydney School of Medicine, Camperdown, NSW, Australia.
The University of Sydney · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo examine the contribution of variation in sex hormone excretion to mood and behavioral changes in adolescent females and males.

designProspective, longitudinal observational cohort study.

methodsParticipants were 342 volunteers aged 10-12 years living in rural Australia. Urinary estradiol and testosterone levels measured by liquid chromatography-mass spectrometry were obtained at three-month intervals for three years. Integrated measures (area-under-curve) of urinary steroid excretion summarised as absolute and variability during each 12-month period of the study. Psychosocial data were gathered annually with the primary outcome of depressive symptomatology. Secondary outcomes were the other subscales of the Youth Self-Report, impulsive-aggression, sleep habits, and self-harm.

results277 (158 male) participants contributed data over the full duration of the study and could be included in the analyses. In females, analyses of absolute urine hormone levels found no relationship between estradiol and any outcome, but higher testosterone was significantly associated with depression and poorer sleep. Greater variability of both urine estradiol and testosterone was associated with lower total psychopathology, anxious/depressed and social problems scores. Greater variability in urine estradiol was associated with lower attention problems and impulsive aggression in females. In males, higher testosterone and estradiol levels were associated with rule-breaking, and poorer sleep, and no associations were found for gonadal hormone variability for males.

conclusionsLongitudinal measurement of both iso-sexual and contra-sexual gonadal hormones contributes to a more nuanced view of the impact of sex steroids on mood and behavior in adolescents. These findings may enlighten the understanding of the impact of sex steroids during normal male and female puberty with implications for hormone replacement therapies as well as management of common mood and behavioral problems.

Indexed as

Gonadal Steroid HormonesTestosteroneAdolescentEstradiolFemaleGonadal HormonesHumansMaleProspective StudiesEstradiolGonadal HormonesGonadal Steroid HormonesTestosterone

Identifiers

PMID37844097
PMCPMC10578568
OpenAlexW4387666480

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.