Evidence map›Paper›PMID 37843756›Full record

ArticleMolecular biotechnology2024

Control Phytophagous Nematodes By Engineering Phytosterol Dealkylation Caenorhabditis elegans as a Model.

Qinhua Gan, Xinyu Cui, Lin Zhang, Wenxu Zhou, Yandu Lu

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qinhua GanState Key Laboratory of Marine Resource Utilization in South China Sea, School of Marine Biology and Fisheries, Hainan University, Hainan Province, 570228, Hainan, China.
Xinyu CuiState Key Laboratory of Marine Resource Utilization in South China Sea, School of Marine Biology and Fisheries, Hainan University, Hainan Province, 570228, Hainan, China.
Lin ZhangShandong Rongchen Pharmaceuticals Inc, Qingdao, 266061, China.
Wenxu ZhouState Key Laboratory of Marine Resource Utilization in South China Sea, School of Marine Biology and Fisheries, Hainan University, Hainan Province, 570228, Hainan, China. wxzhou@hainanu.edu.cn.
Yandu LuState Key Laboratory of Marine Resource Utilization in South China Sea, School of Marine Biology and Fisheries, Hainan University, Hainan Province, 570228, Hainan, China. ydlu@hainanu.edu.cn.ORCID http://orcid.org/0000-0002-0136-2252
Hainan University · CN

Funding

National Key Laboratory of Aerodynamic Design and Research 2021YFA0909600
6 · The paper itself

Abstract

Plant-parasitic nematodes ingest and convert host phytosterols via dealkylation to cholesterol for both structural and hormonal requirements. The insect 24-dehydrocholesterol reductase (DHCR24) was shown in vitro as a committed enzyme in the dealkylation via chemical blocking. However, an increased brood size and ovulation rate, instead compromised development, were observed in the engineered nematode Caenorhabditis elegans where the DHCR24 gene was knocked down, indicating the relationship between DHCR24 and dealkylation and their function in nematodes remains illusive. In this study, a defect in C. elegans DHCR24 causes impaired growth of the nematode with sitosterol (a major component of phytosterols) as a sole sterol source. Plant sterols with rationally designed structure (null substrates for dealkylation) can't be converted to cholesterol in wild-type worms, and their development was completely halted. This study underpins the essential function of DHCR24 in nematodes and would be beneficial for the development of novel nematocidal strategies.

Indexed as

Caenorhabditis elegansPhytosterolsAnimalsCaenorhabditis elegans ProteinsCholesterolOxidoreductases Acting on CH-CH Group DonorsSitosterolsCaenorhabditis elegans ProteinsCholesterolgamma-sitosterolOxidoreductases Acting on CH-CH Group DonorsPhytosterolsSitosterols24-dehydrocholesterol reductaseCholesterolDealkylationNematodePhytosterol

Identifiers

PMID37843756
OpenAlexW4387662025

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.